Handbook of Experimental Pharmacology

Quinolone Antibacterials

Editors: Kuhlmann, Jochen, Dalhoff, A., Zeiler, H.-J. (Eds.)

Free Preview

Buy this book

eBook $119.00
price for USA in USD
  • ISBN 978-3-642-80364-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA in USD
  • ISBN 978-3-642-80366-6
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
About this book

It has been over 30 years since the first clinically important member of the quinolone class, nalidixic acid, was introduced into medical practice. The modification produced in the quinolone nucleus by introducing a fluorine at the 6-position led to the discovery of the newer fluoroquinolones with enhanced antibacterial activities as compared to nalidixic acid. By now a great deal of preclinical and clinical experience has been obtained with these agents. The intense interest in this class of antibacterial agents by chemists, micro­ biologists, toxicologists, pharmacologists, clinical pharmacologists, and clini­ cians in various disciplines encouraged us to summarize the information on the history, chemistry, mode of action and in vitro properties, kinetics and efficacy in animals, mechanisms of resistance, toxicity, clinical pharmacology, clinical experience, and future prospects in one volume of the Handbook of Experimental Pharmacology. As this series deals predominantly with "experimental" characteristics of drugs, our volume is dedicated specifically to quinolones and emphasizes principally their preclinical and clinical phar­ macological characteristics, despite the existence of several summaries on quinolones. The chemistry of the quinolones is described in detail. The chapter on the mode of action of quinolones reports the conclusive evidence that gyrase is the intracellular target of the quinolones; however, another enzyme, topoisomerase IV, may also be a target for quinolones, and the exact mechanisms by which quinolones act bactericidally are far from being understood.

Table of contents (14 chapters)

Table of contents (14 chapters)

Buy this book

eBook $119.00
price for USA in USD
  • ISBN 978-3-642-80364-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA in USD
  • ISBN 978-3-642-80366-6
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Quinolone Antibacterials
Editors
  • Jochen Kuhlmann
  • A. Dalhoff
  • H.-J. Zeiler
Series Title
Handbook of Experimental Pharmacology
Series Volume
127
Copyright
1998
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-80364-2
DOI
10.1007/978-3-642-80364-2
Softcover ISBN
978-3-642-80366-6
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XVIII, 491
Topics