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Medical Oncology
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Evolutionary Biology and Ecology of Cancer

In this collection, we welcome articles that pertain to the subject of how eco-evolutionary principles can be applied to understand tumorigenesis or how eco-evolutionary principles can be applied to develop ...
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CAR T-cell therapy in cancer

Cancer therapy using chimeric antigen receptor (CAR)-T-cells is one of the most exciting recent developments in cancer therapy. To date CAR-T-cells have been successfully used to treat persons with hematolog...
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Regulatory T cells in cancer immunosuppression

A paradox in tumor immunity is the co-existing of growing tumors with circulating or tissue-infiltrating tumor-reactive T cells. The inability of tumor-reactive T cells in control of tumor growth has been at...
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Immune checkpoint inhibitors in cancer treatment

The advent and validation of immune checkpoint inhibitors targeting the T cell receptors PD1 and CTLA have been 'game changers' in clinical cancer therapy. Initially approved for melanoma, lung cancer, and k...
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Mechanisms of resistance to cancer therapy

Metastatic cancer is ultimately resistant to virtually all systemic therapies and continues to kill more than 10 million people per year around the world. This suggests a common mechanism for cancer resistan...
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