Use of population PK/PD approach to model the thrombin generation assay: assessment in haemophilia A plasma samples spiked by a TFPI antibody
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Broadly speaking, the Journal of Pharmacokinetics and Pharmacodynamics covers the area of pharmacometrics. The journal is devoted to illustrating the importance of pharmacokinetics, pharmacodynamics, and pharmacometrics in drug development, clinical care, and the understanding of drug action. The journal publishes on a variety of topics related to pharmacometrics, including, but not limited to, clinical, experimental, and theoretical papers examining the kinetics of drug disposition and effects of drug action in humans, animals, in vitro, or in silico; modeling and simulation methodology, including optimal design; precision medicine; systems pharmacology; and mathematical pharmacology (including computational biology, bioengineering, and biophysics related to pharmacology, pharmacokinetics, orpharmacodynamics). Clinical papers that include population pharmacokinetic-pharmacodynamic relationships are welcome. The journal actively invites and promotes up-and-coming areas of pharmacometric research, such as real-world evidence, quality of life analyses, and artificial intelligence. The Journal of Pharmacokinetics and Pharmacodynamics is an official journal of the International Society of Pharmacometrics.
Journal of Pharmacokinetics and Pharmacodynamics publishes six issues a year.
As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times. Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.
The journal extends its condolences to the family of Editorial Advisory Board Member Hartmut Derendorf, who unexpectedly passed away on November 23, 2020. He was a leader in the field and he contributed to the journal as a reviewer and author. A commentary on his life and legacy will appear shortly. His obituary can be found here.
Chronopharmacology is part of pharmacology that is concerned with effects of biological rhythms while pharmacometrics relates to mathematical models of pharmacokinetics and pharmacodynamics of drugs. Chronopharmacometrics encompasses pharmacometric methods relevant to quantifying chronopharmacology and chronotherapeutics. We are planning a special issue of Journal of Pharmacokinetics and Pharmacodynamics on Chronopharmacometrics in December 2020 to present state-of-the-art modeling approaches that address the presence of biorhythms in biomarkers used in drug development and therapeutics.
We are pleased to announce that Peter Bonate, Ph.D. is the new Editor-in-Chief of Journal of Pharmacokinetics and Pharmacodynamics, commencing January 1st, 2020.
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