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SpringerBriefs in Mathematics

Mathematical Grammar of Biology

Authors: Yamagishi, Michel Eduardo Beleza

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  • Offers the first detailed development of the conceptual theoretical framework necessary to search for DNA’s first principles
  • Shows how mathematical modeling can be applied to the study of DNA’s language 
  • Proves that the results are not only aesthetically beautiful, but are also confirmed by more than 96% of all genomic sequences publicly available
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eBook 41,64 €
price for Spain (gross)
  • ISBN 978-3-319-62689-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover 51,99 €
price for Spain (gross)
  • ISBN 978-3-319-62688-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

This seminal, multidisciplinary book shows how mathematics can be used to study the first principles of DNA. Most importantly, it enriches the so-called “Chargaff’s grammar of biology” by providing the conceptual theoretical framework necessary to generalize Chargaff’s rules. Starting with a simple example of DNA mathematical modeling where human nucleotide frequencies are associated to the Fibonacci sequence and the Golden Ratio through an optimization problem, its breakthrough is showing that the reverse, complement and reverse-complement operators defined over oligonucleotides induce a natural set partition of DNA words of fixed-size. These equivalence classes, when organized into a matrix form, reveal hidden patterns within the DNA sequence of every living organism. Intended for undergraduate and graduate students both in mathematics and in life sciences, it is also a valuable resource for researchers interested in studying invariant genomic properties.

About the authors

Michel Eduardo Beleza Yamagishi is a senior researcher at Embrapa Informática Agropecuária,  working at Embrapa Multiuser Bioinformatics Laboratory. He holds a PhD (2001) and a Master’s  in Applied Mathematics from the University of Campinas (Unicamp). His fields of research include bioinformatics, genomics and optimization problems.

Reviews

“The book presents itself as a inclusive introduction to nucleotide and k-mer frequencies in genomes across the tree of life, having as its focal point the Chargaff parity rule. … The book is written in accessible terms and presents itself as an optimal first exposure to the interdisciplinary field of mathematical biology. It can be enjoyed by a wide range of audiences, but its appeal consists in the possibility of it being read by younger readers.” (Irina Ioana Mohorianu, zbMATH 1395.92002, 2018)

“The volume is appropriate for anyone interested in computational biology and synthetic biology. It is short and easy to read, and provides a refreshing view on many aspects of DNA structure at the level of abstraction of strings over a very short alphabet. The author shows very clearly and convincingly that the question of what is the actual code of life is far from answered.” (Sara Kalvala, Computing Reviews, July, 2018)


Table of contents (4 chapters)

Table of contents (4 chapters)
  • Introduction

    Pages 1-8

    Yamagishi, Michel Eduardo Beleza

  • Modeling Human Nucleotide Frequencies

    Pages 9-27

    Yamagishi, Michel Eduardo Beleza

  • Expanding the Grammar of Biology

    Pages 29-53

    Yamagishi, Michel Eduardo Beleza

  • “In God We Trust; All Others, Bring Data”

    Pages 55-70

    Yamagishi, Michel Eduardo Beleza

Buy this book

eBook 41,64 €
price for Spain (gross)
  • ISBN 978-3-319-62689-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover 51,99 €
price for Spain (gross)
  • ISBN 978-3-319-62688-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Mathematical Grammar of Biology
Authors
Series Title
SpringerBriefs in Mathematics
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
The Editor(s) (if applicable) and The Author(s)
eBook ISBN
978-3-319-62689-5
DOI
10.1007/978-3-319-62689-5
Softcover ISBN
978-3-319-62688-8
Series ISSN
2191-8198
Edition Number
1
Number of Pages
XII, 82
Number of Illustrations
2 b/w illustrations, 17 illustrations in colour
Topics