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Advanced Technologies in Cardiovascular Bioengineering

  • Book
  • © 2022

Overview

Editors:
  1. Jianyi Zhang

    1. Biomedical Engineering, University of Alabama at Birmingham, Birmingham, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Vahid Serpooshan

    1. Biomedical Engineering, Georgia Institute of Technology, Atlanta, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Examines rapidly emerging technologies in the field of cardiovascular tissue engineering

  • Covers state-of-the-art biomanufacturing techniques

  • Presents basic science and engineering concepts, coupled with clinical and translational advancements

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-x
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  2. Cardiac Development and Morphogenesis

    1. Front Matter

      Pages 1-1
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    2. From Simple Cylinder to Four-Chambered Organ: A Brief Overview of Cardiac Morphogenesis

      • Carissa Lee, Sharon L. Paige, Francisco X. Galdos, Nicholas Wei, Sean M. Wu
      Pages 3-14

    3. Lineage Tracing Models to Study Cardiomyocyte Generation During Cardiac Development and Injury

      • Kamal Kolluri, Bin Zhou, Reza Ardehali
      Pages 15-29

    4. Mechanisms that Govern Endothelial Lineage Development and Vasculogenesis

      • Daniel J. Garry, Javier E. Sierra-Pagan
      Pages 31-48

  4. Genetic Approaches to Study Cardiac Differentiation and Repair

    1. Front Matter

      Pages 123-123
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    2. Analysing Genetic Programs of Cell Differentiation to Study Cardiac Cell Diversification

      • Zhixuan Wu, Sophie Shen, Yuliangzi Sun, Tessa Werner, Stephen T. Bradford, Nathan J. Palpant
      Pages 125-167

    3. Recombinant Adeno-Associated Virus for Cardiac Gene Therapy

      • Cindy Kok, Dhanya Ranvindran, Eddy Kizana
      Pages 169-190

  5. Bioengineering Approaches to Cardiovascular Tissue Modeling and Repair

    1. Front Matter

      Pages 191-191
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    2. Microfabricated Systems for Cardiovascular Tissue Modeling

      • Ericka Jayne Knee-Walden, Karl Wagner, Qinghua Wu, Naimeh Rafatian, Milica Radisic
      Pages 193-232

    3. Bioengineering of Pediatric Cardiovascular Constructs: In Vitro Modeling of Congenital Heart Disease

      • Holly Bauser-Heaton, Carmen J. Gil, Vahid Serpooshan
      Pages 233-248

    4. Biomaterial Interface in Cardiac Cell and Tissue Engineering

      • Chenyan Wang, Zhen Ma
      Pages 249-280

    5. Stem Cell-Based 3D Bioprinting for Cardiovascular Tissue Regeneration

      • Clara Liu Chung Ming, Eitan Ben-Sefer, Carmine Gentile
      Pages 281-312

    6. Creating and Validating New Tools to Evaluate the Electrical Integration and Function of hPSC-Derived Cardiac Grafts In Vivo

      • Wahiba Dhahri, Fanny Wulkan, Michael A. Laflamme
      Pages 313-332

  6. Clinical Perspectives

    1. Front Matter

      Pages 333-333
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Keywords

About this book

This book presents a systematic overview of the technologies currently being explored and utilized in the fields of cardiovascular tissue engineering and regenerative medicine. Considering the unprecedented rapid progress occurring on multiple technological fronts in cardiac tissue engineering, this important new volume fills a need for an up-to-date, comprehensive text on emerging advanced biological and engineering tools. The book is an important resource for anyone looking to understand the emerging topics that have the potential to substantially influence the future of the field. Coverage includes iPS stem cell technologies, nanotechnologies and nanomedicine, advanced biomanufacturing, 3D culture systems, 3D organoid systems, genetic approaches to cardiovascular tissue engineering, and organ on a chip. This book will be a valuable guide for research scientists, students, and clinical researchers in the fields of cardiovascular biology, medicine, and bioengineering, as well as industry-based practitioners working in biomaterial science, nanomaterials and technology, and rapid prototyping and biomanufacturing (3D bioprinting). 

Editors and Affiliations

  • Biomedical Engineering, University of Alabama at Birmingham, Birmingham, USA

    Jianyi Zhang

  • Biomedical Engineering, Georgia Institute of Technology, Atlanta, USA

    Vahid Serpooshan

About the editors

Jianyi “Jay” Zhang, M.D., Ph.D., F.A.H.A., is an international leader in myocardial bioenergetics, biomaterials, and pluripotent stem cells (PSC) for cardiac repair. He is tenured Professor of Medicine and of Engineering; T. Michael and Gillian Goodrich Endowed Chair of Engineering Leadership; and the Chair of the Department of Biomedical Engineering (BME), a joint department of the School of Medicine and School of Engineering, at the University of Alabama at Birmingham (UAB). He came to UAB in 2015 after he was chosen in a national search to lead the UAB BME department from the University of Minnesota Medical School, where he was the Engdahl Family Foundation Chair in Cardiovascular Regenerative Therapies, in addition to being a tenured professor of medicine, of biomedical engineering, of electrical engineering, and computer engineering. Dr. Zhang earned his M.D. from Shanghai Medical University and his Ph.D. in biomedical engineering from the University of Minnesota. He also earned a Master of Science in engineering and a certificate of business administration from Tuft University. Prior to joining the faculty at the University of Minnesota, Dr. Zhang completed postdoctoral work in that university’s cardiovascular division. His research interests include tissue engineering, myocardial energetics in hearts with postinfarction left-ventricle remodeling, heart failure, biomaterials, and human induced pluripotent stem cells for cardiac repair. He is currently the principal investigator of four R01 NIH grants in the fields of myocardial bioenergetics, biomaterials, and stem cells for cardiac repair, NIH BIB T32 training grant, and an NIH U01 grant for the NHLBI Progenitor Cell Translational Consortium (PCTC) on cardiovascular tissue engineering, which continuous through 2025.



Vahid Serpooshan, PhD, earned his BSc and MSc in materials science and engineering at Sharif University and his PhD in biomaterials and tissue engineering at McGill University. His PhD thesis research focused on the design and optimization of scaffolding biomaterials for bone tissue engineering applications. Following his PhD, Dr. Serpooshan worked for seven years at Stanford University School of Medicine as a Postdoctoral Fellow (Pediatric Cardiology) and Instructor (Stanford Cardiovascular Institute). At Stanford, Dr. Serpooshan's training and research were mainly centered on developing a new generation of an engineered cardiac patch device to repair damaged heart tissue following myocardial infarction (heart attack). The engineered patch was successfully tested in mouse and pig models and is now in preparation for clinical trials. He also worked on enabling technologies for human-machine hybrid cardiac tissue, using 3D bioprinting to assemble complex arrays of interfaces between synthetic and biological materials. In 2018, Dr. Serpooshan joined Emory University and Georgia Institute of Technology as an Assistant Professor of Biomedical Engineering and Pediatrics, where his multidisciplinary team is now working on a variety of 3D bioprinting-based tissue engineering and disease modeling projects.

Bibliographic Information

  • Book Title: Advanced Technologies in Cardiovascular Bioengineering

  • Editors: Jianyi Zhang, Vahid Serpooshan

  • DOI: https://doi.org/10.1007/978-3-030-86140-7

  • Publisher: Springer Cham

  • eBook Packages: Engineering, Engineering (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022

  • Hardcover ISBN: 978-3-030-86139-1Published: 06 February 2022

  • Softcover ISBN: 978-3-030-86142-1Published: 07 February 2023

  • eBook ISBN: 978-3-030-86140-7Published: 05 February 2022

  • Edition Number: 1

  • Number of Pages: X, 407

  • Number of Illustrations: 74 b/w illustrations

  • Topics: Biomedical Engineering and Bioengineering, Regenerative Medicine/Tissue Engineering, Biomaterials

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