Overview
- Editors:
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Jianyi Zhang
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Biomedical Engineering, University of Alabama at Birmingham, Birmingham, USA
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Vahid Serpooshan
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Biomedical Engineering, Georgia Institute of Technology, Atlanta, USA
Examines rapidly emerging technologies in the field of cardiovascular tissue engineering
Covers state-of-the-art biomanufacturing techniques
Presents basic science and engineering concepts, coupled with clinical and translational advancements
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Table of contents (17 chapters)
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Cardiac Development and Morphogenesis
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- Carissa Lee, Sharon L. Paige, Francisco X. Galdos, Nicholas Wei, Sean M. Wu
Pages 3-14
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- Kamal Kolluri, Bin Zhou, Reza Ardehali
Pages 15-29
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- Daniel J. Garry, Javier E. Sierra-Pagan
Pages 31-48
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Cellular Approaches to Cardiac Repair and Regeneration
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- Sangho Lee, Young-sup Yoon
Pages 87-102
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- Tim Stüdemann, Florian Weinberger
Pages 103-122
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Genetic Approaches to Study Cardiac Differentiation and Repair
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Front Matter
Pages 123-123
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- Zhixuan Wu, Sophie Shen, Yuliangzi Sun, Tessa Werner, Stephen T. Bradford, Nathan J. Palpant
Pages 125-167
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- Cindy Kok, Dhanya Ranvindran, Eddy Kizana
Pages 169-190
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Bioengineering Approaches to Cardiovascular Tissue Modeling and Repair
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Front Matter
Pages 191-191
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- Ericka Jayne Knee-Walden, Karl Wagner, Qinghua Wu, Naimeh Rafatian, Milica Radisic
Pages 193-232
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- Holly Bauser-Heaton, Carmen J. Gil, Vahid Serpooshan
Pages 233-248
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- Clara Liu Chung Ming, Eitan Ben-Sefer, Carmine Gentile
Pages 281-312
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- Wahiba Dhahri, Fanny Wulkan, Michael A. Laflamme
Pages 313-332
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Clinical Perspectives
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Front Matter
Pages 333-333
About this book
This book presents a systematic overview of the technologies currently being explored and utilized in the fields of cardiovascular tissue engineering and regenerative medicine. Considering the unprecedented rapid progress occurring on multiple technological fronts in cardiac tissue engineering, this important new volume fills a need for an up-to-date, comprehensive text on emerging advanced biological and engineering tools. The book is an important resource for anyone looking to understand the emerging topics that have the potential to substantially influence the future of the field. Coverage includes iPS stem cell technologies, nanotechnologies and nanomedicine, advanced biomanufacturing, 3D culture systems, 3D organoid systems, genetic approaches to cardiovascular tissue engineering, and organ on a chip. This book will be a valuable guide for research scientists, students, and clinical researchers in the fields of cardiovascular biology, medicine, and bioengineering, as well as industry-based practitioners working in biomaterial science, nanomaterials and technology, and rapid prototyping and biomanufacturing (3D bioprinting).
Editors and Affiliations
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Biomedical Engineering, University of Alabama at Birmingham, Birmingham, USA
Jianyi Zhang
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Biomedical Engineering, Georgia Institute of Technology, Atlanta, USA
Vahid Serpooshan
About the editors
Jianyi “Jay” Zhang, M.D., Ph.D., F.A.H.A., is an international leader in myocardial bioenergetics, biomaterials, and pluripotent stem cells (PSC) for cardiac repair. He is tenured Professor of Medicine and of Engineering; T. Michael and Gillian Goodrich Endowed Chair of Engineering Leadership; and the Chair of the Department of Biomedical Engineering (BME), a joint department of the School of Medicine and School of Engineering, at the University of Alabama at Birmingham (UAB). He came to UAB in 2015 after he was chosen in a national search to lead the UAB BME department from the University of Minnesota Medical School, where he was the Engdahl Family Foundation Chair in Cardiovascular Regenerative Therapies, in addition to being a tenured professor of medicine, of biomedical engineering, of electrical engineering, and computer engineering. Dr. Zhang earned his M.D. from Shanghai Medical University and his Ph.D. in biomedical engineering from the University of Minnesota. He also earned a Master of Science in engineering and a certificate of business administration from Tuft University. Prior to joining the faculty at the University of Minnesota, Dr. Zhang completed postdoctoral work in that university’s cardiovascular division. His research interests include tissue engineering, myocardial energetics in hearts with postinfarction left-ventricle remodeling, heart failure, biomaterials, and human induced pluripotent stem cells for cardiac repair. He is currently the principal investigator of four R01 NIH grants in the fields of myocardial bioenergetics, biomaterials, and stem cells for cardiac repair, NIH BIB T32 training grant, and an NIH U01 grant for the NHLBI Progenitor Cell Translational Consortium (PCTC) on cardiovascular tissue engineering, which continuous through 2025.
Vahid Serpooshan, PhD, earned his BSc and MSc in materials science and engineering at Sharif University and his PhD in biomaterials and tissue engineering at McGill University. His PhD thesis research focused on the design and optimization of scaffolding biomaterials for bone tissue engineering applications. Following his PhD, Dr. Serpooshan worked for seven years at Stanford University School of Medicine as a Postdoctoral Fellow (Pediatric Cardiology) and Instructor (Stanford Cardiovascular Institute). At Stanford, Dr. Serpooshan's training and research were mainly centered on developing a new generation of an engineered cardiac patch device to repair damaged heart tissue following myocardial infarction (heart attack). The engineered patch was successfully tested in mouse and pig models and is now in preparation for clinical trials. He also worked on enabling technologies for human-machine hybrid cardiac tissue, using 3D bioprinting to assemble complex arrays of interfaces between synthetic and biological materials. In 2018, Dr. Serpooshan joined Emory University and Georgia Institute of Technology as an Assistant Professor of Biomedical Engineering and Pediatrics, where his multidisciplinary team is now working on a variety of 3D bioprinting-based tissue engineering and disease modeling projects.