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Drug Delivery and Targeting

  • Book
  • © 2024

Overview

Editors:
  1. Monika Schäfer-Korting

    1. Pharmacology and Toxicology, Freie Universität Berlin, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Ulrich S. Schubert

    1. Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Jena, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Integrates drug delivery, pharmacology and therapy
  • Bridges chemistry, physics of the vehicle and innovative drugs
  • Maximizes reader insights into cutting-edge therapies

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 284)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-x
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  2. Nanoparticles and Other Advanced Technologies

    1. Front Matter

      Pages 1-1
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    2. Knowledge-Based Design of Multifunctional Polymeric Nanoparticles

      • Mira Behnke, Caroline T. Holick, Antje Vollrath, Stephanie Schubert, Ulrich S. Schubert
      Pages 3-26

    3. Stimuli-Responsive Non-viral Nanoparticles for Gene Delivery

      • Liên S. Reichel, Anja Traeger
      Pages 27-43

    4. Sustainability in Drug and Nanoparticle Processing

      • Dagmar Fischer
      Pages 45-68

    5. Advanced Formulation Approaches for Proteins

      • Corinna S. Schlosser, Gareth R. Williams, Karolina Dziemidowicz
      Pages 69-91

    6. Microneedle and Polymeric Films: Delivery of Proteins, Peptides and Nucleic Acids

      • Yu Wu, Aaron R. J. Hutton, Anjali Kiran Pandya, Vandana B. Patravale, Ryan F. Donnelly
      Pages 93-111

    7. Advances in Vaccine Adjuvants: Nanomaterials and Small Molecules

      • Bingbing Sun, Min Li, Zhiying Yao, Ge Yu, Yubin Ma
      Pages 113-132

    8. Biodegradable Long-Acting Injectables: Platform Technology and Industrial Challenges

      • Marieta Duvnjak, Alessia Villois, Farshad Ramazani
      Pages 133-150

  3. Visualization Technologies

    1. Front Matter

      Pages 151-151
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    2. Visualization of Nanocarriers and Drugs in Cells and Tissue

      • Ulrike Alexiev, Eckart Rühl
      Pages 153-189

    3. Characterization of Drug Delivery Systems by Transmission Electron Microscopy

      • Stephanie Hoeppener
      Pages 191-209

  4. Target Specific Delivery

    1. Front Matter

      Pages 211-211
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    2. Blood-Brain Barrier (BBB)-Crossing Strategies for Improved Treatment of CNS Disorders

      • Wandong Zhang
      Pages 213-230

    3. Nanomedicine – Immune System Interactions: Limitations and Opportunities for the Treatment of Cancer

      • Sara Elsafy, Josbert Metselaar, Twan Lammers
      Pages 231-265

    4. Progress in Ocular Drug Delivery: Challenges and Constraints

      • Ilva D. Rupenthal, Priyanka Agarwal
      Pages 267-288

    5. New Therapeutic Options in Pulmonal Diseases: Sphingolipids and Modulation of Sphingolipid Metabolism

      • Burkhard Kleuser, Fabian Schumacher, Erich Gulbins
      Pages 289-312

    6. Targeted Molecular Therapeutics for Pulmonary Diseases: Addressing the Need for Precise Drug Delivery

      • Simone Carneiro, Joschka T. Müller, Olivia M. Merkel
      Pages 313-328

    7. RNA Delivery to Mitochondria

      • Yuma Yamada, Hideyoshi Harashima
      Pages 329-339

  5. Concerted Actions – Thinking the Drug from the Beginning

    1. Front Matter

      Pages 341-341
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Keywords

About this book

Since the publication of the Handbook of Experimental Pharmacology Vol. 197 in 2010 there have been important advances in drug development, drug delivery and – more recently – drug targeting. This is in particular relevant with the new generation of drugs acting on the immune system and tumors. These are quite often accompanied by major adverse reactions. Safe therapy is, therefore, an important area of research, in particular in chronic diseases and in persons of old age. In addition, the Covid-19 pandemic has brought renewed attention to vaccinations against viral infections, and mRNA vaccines have been tested for vaccination in tumor therapy, too. Vaccine delivery has stimulated important research on carriers which may pave the way for other applications and enhance a path to e.g. CRISPR-cas therapy.


Editors and Affiliations

  • Pharmacology and Toxicology, Freie Universität Berlin, Berlin, Germany

    Monika Schäfer-Korting

  • Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Jena, Germany

    Ulrich S. Schubert

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