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Human iPSC-derived Disease Models for Drug Discovery

  • Book
  • © 2023

Overview

Editors:
  1. Markus H. Kuehn

    1. Center for Prevention and Treatment of Visual Loss; Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, USA

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  2. Wei Zhu

    1. School of Pharmacy, Qingdao University, Qingdao, China

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    You can also search for this editor in PubMed   Google Scholar

  • Provides an exhaustive review of use of iPSC in pharmaceutics, iPSC-based modeling and materials science
  • Broadens your understanding of iPSC to model diseases of cardiovascular system, nervous system and ophthalmology
  • Presents iPSC-derived disease models that accelerate the development of pharmacologic treatments

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 281)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
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  2. iPSC Production for Pharmaceutical Research

    1. Front Matter

      Pages 1-1
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    2. Human iPS Cells for Clinical Applications and Cellular Products

      • Moyra Lawrence
      Pages 3-27

    3. 3D Bioprinting of Induced Pluripotent Stem Cells and Disease Modeling

      • Shaojun Liang, Yijun Su, Rui Yao
      Pages 29-56

  3. CNS iPSC and Organoids

    1. Front Matter

      Pages 57-57
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    2. iPSCs-Derived Neurons and Brain Organoids from Patients

      • Wanying Zhu, Lei Xu, Xinrui Li, Hao Hu, Shuning Lou, Yan Liu
      Pages 59-81

    3. Retinal Ganglion Cells in a Dish: Current Strategies and Recommended Best Practices for Effective In Vitro Modeling of Development and Disease

      • Kang-Chieh Huang, Cátia Gomes, Jason S. Meyer
      Pages 83-102

    4. Applications of Induced Pluripotent Stem Cell-Derived Glia in Brain Disease Research and Treatment

      • Zhiqi Yang, Mingyue Gong, Chuanyan Yang, Chunhai Chen, Kuan Zhang
      Pages 103-140

    5. Human-Induced Pluripotent Stem Cell-Based Model of the Blood-Brain at 10 Years: A Retrospective on Past and Current Disease Models

      • Abraham J. Al-Ahmad
      Pages 141-156

    6. Human Retinal Organoids in Therapeutic Discovery: A Review of Applications

      • Lin Cheng, Markus H. Kuehn
      Pages 157-187

  4. iPSC-Derived Nociceptive Neurons

    1. Front Matter

      Pages 189-189
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    2. Using Human iPSC-Derived Peripheral Nervous System Disease Models for Drug Discovery

      • Yuan Gao
      Pages 191-205

  5. Non-Neuronal Specialized Cell Types

    1. Front Matter

      Pages 207-207
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    2. Human-Induced Pluripotent Stem Cell-Based Differentiation of Cardiomyocyte Subtypes for Drug Discovery and Cell Therapy

      • Ziwei Pan, Ping Liang
      Pages 209-233

    3. Cardiac Disease Modeling with Engineered Heart Tissue

      • Lin Cai, Ruxiang Wang, Donghui Zhang
      Pages 235-255

    4. iPSC-Derived Corneal Endothelial Cells

      • Qingjun Zhou, Zongyi Li, Haoyun Duan
      Pages 257-276

    5. iPSCs-Based Therapy for Trabecular Meshwork

      • Wei Zhu, Xiaoyan Zhang, Shen Wu, Ningli Wang, Markus H. Kuehn
      Pages 277-300

    6. Harnessing Human Pluripotent Stem Cell-Derived Pancreatic In Vitro Models for High-Throughput Toxicity Testing and Diabetes Drug Discovery

      • Carmen Ching, Elhadi Iich, Adrian Kee Keong Teo
      Pages 301-332
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Keywords

About this book

Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has beenlost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations.

Editors and Affiliations

  • Center for Prevention and Treatment of Visual Loss; Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, USA

    Markus H. Kuehn

  • School of Pharmacy, Qingdao University, Qingdao, China

    Wei Zhu

Bibliographic Information

  • Book Title: Human iPSC-derived Disease Models for Drug Discovery

  • Editors: Markus H. Kuehn, Wei Zhu

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-031-42349-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023

  • Hardcover ISBN: 978-3-031-42348-2Published: 24 November 2023

  • Softcover ISBN: 978-3-031-42351-2Due: 25 December 2023

  • eBook ISBN: 978-3-031-42349-9Published: 23 November 2023

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: VIII, 332

  • Number of Illustrations: 70 b/w illustrations, 30 illustrations in colour

  • Topics: Neurosciences, Regenerative Medicine/Tissue Engineering, Stem Cells

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