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Toll-like Receptors in Health and Disease

  • Book
  • © 2022

Overview

Editors:
  1. Vijay Kumar

    1. Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center (DUMC), Durham, USA

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  • Enriches understanding of TLRs in diverse conditions varying from immune homoestasis to drug targeting
  • Equips readers to handle the complexities of immunity through TLRs
  • Simplifies the complexities to understanding TLRs in immunity and inflammatory diseases

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 276)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Toll-Like Receptors (TLRs) in Health and Disease: An Overview

    • Vijay Kumar, James E. Barrett
    Pages 1-21

  3. Signal-Strength and History-Dependent Innate Immune Memory Dynamics in Health and Disease

    • Shuo Geng, Kisha Pradhan, Liwu Li
    Pages 23-41

  4. Innate Neutrophil Memory Dynamics in Disease Pathogenesis

    • RuiCi Lin, Liwu Li
    Pages 43-64

  5. Cell-Specific Expression Pattern of Toll-Like Receptors and Their Roles in Animal Reproduction

    • Mehmet Osman Atli, Mustafa Hitit, Mehmet Özbek, Mehmet Köse, Faruk Bozkaya
    Pages 65-93

  6. Toll-Like Receptors in Adaptive Immunity

    • Vijay Kumar
    Pages 95-131

  7. Intracellular TLRs of Mast Cells in Innate and Acquired Immunity

    • Youichi Ogawa, Manao Kinoshita, Tatsuyoshi Kawamura, Shinji Shimada
    Pages 133-159

  8. TLR10 and Its Role in Immunity

    • Faith Fore, Melisa Budipranama, Rian Anggia Destiawan
    Pages 161-174

  9. Toll-Like Receptors in Stem/Progenitor Cells

    • Fabio Sallustio, Angela Picerno, Marco Tatullo, Antonio Rampino, Carlo Rengo, Alessandra Valletta et al.
    Pages 175-212

  10. TLR Signaling in Brain Immunity

    • Mengdi Guo, Yun Xu, Cun-Jin Zhang
    Pages 213-237

  11. Toll-Like Receptor 4 in Pain: Bridging Molecules-to-Cells-to-Systems

    • Sanam Mustafa, Samuel Evans, Benjamin Barry, Daniel Barratt, Yibo Wang, Cong Lin et al.
    Pages 239-273

  12. Toll-Like Receptor 4: A Novel Target to Tackle Drug Addiction?

    • Jianfeng Liu, Jun-Xu Li, Ruyan Wu
    Pages 275-290

  13. Toll-Like Receptors as Drug Targets in the Intestinal Epithelium

    • Declan P. McKernan
    Pages 291-314
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Keywords

About this book

The current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopolysaccharide (LPS). This discovery revolutionized the field of innate immunity and filled the long-standing gap in the pathogen recognition by the immune system. Now, it is well established that humans have 10 (TLR1-TLR10) and mice have 12 (TLR1-TLR13) functional TLRs, excluding TLR10 that is present as a defective pseudogene. TLRs are present as both membrane-bound extracellular (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) and intracellular (TLR3, TLR7, TLR8, and TLR9) PRRs in humans, which identify different pathogen or microbe-associated molecular patterns (PAMPs or MAMPs) and death or damage-associated molecular patterns (DAMPs) released by the host cells. A lot of development in the TLR biology has occurred in last 24 years since there first discovery in humans.

The book is intended to describe their role in the host defence, human reproduction, non-infectious sterile inflammatory conditions, including brain immunity and cerebrovascular diseases, signaling mechanisms, adaptive immunity, and their targeting for drug development.

Editors and Affiliations

  • Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center (DUMC), Durham, USA

    Vijay Kumar

Bibliographic Information

  • Book Title: Toll-like Receptors in Health and Disease

  • Editors: Vijay Kumar

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-031-06512-5

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022

  • Hardcover ISBN: 978-3-031-06511-8Published: 07 June 2022

  • Softcover ISBN: 978-3-031-06514-9Published: 08 June 2023

  • eBook ISBN: 978-3-031-06512-5Published: 06 June 2022

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: VIII, 314

  • Number of Illustrations: 70 b/w illustrations, 30 illustrations in colour

  • Topics: Pharmacology/Toxicology, Immunology

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