Overview
- Editors:
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Donna H. Wang
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Department of Medicine, Michigan State University, East Lansing
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Table of contents (34 protocols)
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Assays For Determination of Protein Contents and Enzyme Activity
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- Zhi-Qin Wang, Robert M. Carey
Pages 237-244
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- Nageswara R. Madamanchi, Marschall S. Runge
Pages 245-256
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- Qing Cheng Meng, Kathleen H. Berecek
Pages 257-266
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- Qing Cheng Meng, Kathleen H. Berecek
Pages 267-273
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- Robert C. Speth, Joseph W. Harding
Pages 275-295
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- Jacqueline Pérodin, Antony A. Boucard, Richard Leduc, Emanuel Escher, Gaétan Guillemette
Pages 297-303
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- Gaétan Thibault, Ernesto L. Schiffrin
Pages 305-314
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- Siew Yeen Chai, Andrew M. Allen, Jialong Zhuo, Ingrid Moeller, Frederick A. O. Mendelsohn
Pages 315-337
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Biochemical Studies of The Renin-Angiotensin System
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Front Matter
Pages 339-339
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- Rhian M. Touyz, Ernesto L. Schiffrin
Pages 341-354
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- Rhian M. Touyz, Ernesto L. Schiffrin
Pages 355-362
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- Christian Thorup, Leon C. Moore
Pages 379-389
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- Armin Kurtz, Frank Schweda
Pages 391-404
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Functional Studies of The Renin-Angiotensin System
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Front Matter
Pages 405-405
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- Richard J. Roman, David L. Mattson, Allen W. Cowley Jr.
Pages 407-426
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- John D. Imig, L. Gabriel Navar
Pages 427-434
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- Jeffrey L. Garvin, Peter J. Harris
Pages 451-470
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- Jos P. M. Wesselman, Paul H. Ratz, Russell L. Prewitt
Pages 471-487
About this book
A qualitative leap in the understanding of cardiovascular and n- ral regulation by the renin–angiotensin system, and of the role of this s- tem in tissue damage, has occurred as a result of the many recent advances in molecular genetic techniques. The cloning of the genes for the components of the renin–angiotensin system, the design of specific angiotensin receptor ligands, and the use of embryonic gene targeting te- niques for the creation of mutant strains have established that the renin– angiotensin system is important in blood pressure regulation, ion and fluid homeostasis, and tissue growth and remodeling Further investigation of the mechanisms by which this system p- ticipates in cardiovascular regulation may shed some light on the pat- genesis of several cardiovascular diseases, e. g. , hypertension, congestive heart failure, and chronic renal failure. Despite the promise of this system as a target for therapeutic interventions for these diseases, there are great challenges in the integration of the attempts to close the gap between the traditional literature of medicine and the explosion of information from the new technologies. This book’s title, Angiotensin Protocols, reflects the authors’ strong efforts to translate expert knowledge into easy-to-follow practice. The book opens with introductory chapters, and each specialty section provides detailed methods covering a wide variety of techniques, ranging from genetic manipulation of targeted genes to functional studies of the renin– angiotensin system.
Reviews
"This is an advanced treatise on the renin-angiotensin system (RAS) and its regulation of the cardiovascular, renal, and neural relationships in health and disease. The introduction is ample to move the biological scientist reader up to adequacy to comprehend a complex patient example. ...The purpose shows a goal along with suitable objectives to move traditional medicine into utilization of the amazing explosion of modern biological techniques in RAS applications. It does so with a compilation of experts that foster a clearer picture of the modem RAS field. These are indeed worthy objectives, that surpass what individual papers and review articles can accomplish. Indeed it is needed and it serves as a tremendous thinking stimulator....The introduction by John E. Hall sets the tone and makes this book happen. The genetic manipulation of the RAS by Sigmund and Stec keeps the happening alive. the quantification of angiotensin II receptors by Wu, Yao and Wang is an outstanding peace of work. The cyclic AMP and GMP by Ji was helpful as was the NO from assay work of Thorup and Moore. The closing article on cerebral circulation by Lombard carries the exciting nature of the book to the interested student."-Doody's Health Sciences Book Review Journal
"This book with great attention to the recent developments in molecular genetic, biochemical and fysiological techniques can be recommended to all researchers involved in the fundemental research of the RAS at the cellular level." - Acta Cardiologica
Editors and Affiliations
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Department of Medicine, Michigan State University, East Lansing
Donna H. Wang