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Taurine 4

Taurine and Excitable Tissues

  • Book
  • © 2002

Overview

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 483)

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Table of contents (69 chapters)

  1. Metabolic and Nutritional Aspects

  2. Taurine in the CNS

  3. Taurine Analogues and Metals: Health Care Aspects pported by COST D8 and D13

Keywords

About this book

Mitochondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mitochondrial membrane 2+ + potential ?? and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mitochondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the “setpoint” andcorresponds to values between 0.3-3µM. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mitochondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca /2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca /2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein. ?? membrane potential. ? pH gradient. Adapted from .

Editors and Affiliations

  • University of Florence, Florence, Italy

    Laura Corte

  • University of Arizona College of Medicine, Tucson

    Ryan J. Huxtable

  • University of Siena, Siena, Italy

    Giampietro Sgaragli

  • Trinity College, Dublin, Ireland

    Keith F. Tipton

Bibliographic Information

  • Book Title: Taurine 4

  • Book Subtitle: Taurine and Excitable Tissues

  • Editors: Laura Corte, Ryan J. Huxtable, Giampietro Sgaragli, Keith F. Tipton

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/b112581

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2002

  • Hardcover ISBN: 978-0-306-46447-8Published: 31 January 2001

  • Softcover ISBN: 978-1-4757-7342-2Published: 12 March 2013

  • eBook ISBN: 978-0-306-46838-4Published: 07 December 2005

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXIV, 652

  • Topics: Biochemistry, general, Pharmacology/Toxicology, Nutrition, Neurology

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