Overview
- Diagnosis of brain tumors, including imaging techniques
- Therapy for brain tumors and its effectiveness
- Biomarkers for brain tumors
- Molecular genetics of brain tumors
- Genetics of epilepsy
Part of the book series: Tumors of the Central Nervous System (TCNS, volume 5)
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Table of contents (30 chapters)
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Astrocytomas
Keywords
About this book
The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The role of cancer stem cells in the initiation and persistence of malignant gliomas is explained; response of glioblastoma cancer stem cells to various growth factors, such as epidermal growth factor receptor kinase inhibitor, is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiation therapy for glioblastoma patients is included. Biological impediments for chemotherapy and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed. Also included are proton magnetic resonance spectroscopy in intracranial gliomas, and the use of proton magnetic spectroscopic imaging in determining the infiltration zone in gliomas. The role of molecular signaling in the CNS cancer development is explained, including cell death signaling in glioblastoma multiforme.
The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The role of cancer stemcells in the initiation and persistence of malignant gliomas is explained; response of glioblastoma cancer stem cells to various growth factors, such as epidermal growth factor receptor kinase inhibitor, is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiation therapy for glioblastoma patients is included. Biological impediments for chemotherapy and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed. Also included are proton magnetic resonance spectroscopy in intracranial gliomas, and the use of proton magnetic spectroscopic imaging in determining the infiltration zone in gliomas. The role of molecular signaling in the CNS cancer development is explained, including cell death signaling in glioblastoma multiforme.
Reviews
From the reviews:
“This book covers the molecular, medical, radiosurgical, and surgical management of intracranial tumors including astrocytomas, hemangioblastomas, and gangliogliomas. The purpose is to address the most recent advances in the management of these tumors. Neurologists, neurosurgeons, and radiologists are the intended audience. … This is an excellent contribution to neurosurgery and should be part of most academic neurosurgery and neurology libraries.” (Celso Agner, Doody’s Review Service, April, 2012)
Editors and Affiliations
Bibliographic Information
Book Title: Tumors of the Central Nervous System, Volume 5
Book Subtitle: Astrocytomas, Hemangioblastomas, and Gangliogliomas
Editors: M.A. Hayat
Series Title: Tumors of the Central Nervous System
DOI: https://doi.org/10.1007/978-94-007-2019-0
Publisher: Springer Dordrecht
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Science+Business Media B.V. 2012
Hardcover ISBN: 978-94-007-2018-3Published: 28 September 2011
Softcover ISBN: 978-94-007-3826-3Published: 27 November 2013
eBook ISBN: 978-94-007-2019-0Published: 28 September 2011
Series ISSN: 2215-096X
Series E-ISSN: 2215-0978
Edition Number: 1
Number of Pages: XXVI, 290
Topics: Cancer Research, Neuroradiology, Neurosurgery, Oncology, Surgery, Pathology