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A Guide to Bone Marrow Transplantation

Overview

Authors:
  1. Hans Joachim Deeg

    1. Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, N.W., USA

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  2. Hans-Georg Klingemann

    1. Leukemia/Bone Marrow Transplant Program of B.C., University of British Columbia, Vancouver, Canada

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  3. Gordon L. Phillips

    1. Leukemia/Bone Marrow Transplant Program of B.C., University of British Columbia, Vancouver, Canada

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Table of contents (24 chapters)

  1. Front Matter

    Pages I-VIII
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  2. Introduction

    1. Introduction

      • H. J. Deeg
      Pages 1-3

  3. Pre-Transplant Considerations

    1. Front Matter

      Pages 5-5
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    2. How Should Marrow Transplantation be Approached?

      • H. J. Deeg
      Pages 7-17

    3. When Should Marrow Transplantation be Considered?

      • H.-G. Klingemann
      Pages 18-25

    4. Preparation for Marrow Transplantation

      • G. L. Phillips
      Pages 26-42

    5. Who Pays?

      • H. J. Deeg
      Pages 43-44

  4. Transplant Procedure

    1. Front Matter

      Pages 45-45
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    2. Donor Selection

      • H. J. Deeg
      Pages 47-52

    3. Conditioning Regimens

      • G. L. Phillips
      Pages 53-70

    4. Collection, Processing and Infusion of Marrow

      • H.-G. Klingemann
      Pages 71-77

  5. Acute Transplant Related Problems

    1. Front Matter

      Pages 79-79
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    2. Side Effects of Conditioning

      • G. L. Phillips
      Pages 81-85

    3. Acute Graft-versus-Host Disease

      • H. J. Deeg
      Pages 86-98

    4. Marrow Graft Failure

      • H. J. Deeg
      Pages 99-106

    5. The Management of Infections

      • G. L. Phillips
      Pages 107-113

    6. Interstitial Pneumonitis

      • H. J. Deeg
      Pages 114-122

    7. Hepatic Dysfunction

      • H.-G. Klingemann
      Pages 123-134

    8. Urinary Tract

      • H.-G. Klingemann
      Pages 135-139

    9. Central Nervous System (CNS)

      • H.-G. Klingemann
      Pages 140-148
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Keywords

About this book

In the late 1940s investigators observed that mice given supralethai doses of total body irradiation were protected by infusion of viable spleen or marrow cells following irradiation, and that this was accomplished by hemopoietic reconsti­ tution with donor cells as proven using genetic markers. If a similar approach could be applied to humans, it should be possible to treat leukemia patients with any dose of chemoradiotherapy as far as nonmarrow toxicity permitted, and then rescue them by marrow transplantation. Early clinical attempts were gen­ erally unsuccessful, mostly due to a lack of knowledge of histocompatibility antigens and appropriate supportive care. These areas developed rather quickly during the 1960s, and for almost two decades now clinical marrow transplan­ tation has been carried out with increasing success. After initially using only bone marrow from HLA indentical siblings, the field has expanded rapidly to incorporate HLA nonidentical related donors, and recently even marrow from unrelated volunteer donors. Furthermore, since for numerous patients who oth­ erwise could benefit from transplantation a donor cannot be identified, there has been a growing interest in using the patient's own (autologous) bone marrow. Our understanding of the principles of transplantation and our knowledge of the potential risks and benefits have quickly grown. At times it is difficult, however, to decide what is the best option for a given patient.

Authors and Affiliations

  • Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, N.W., USA

    Hans Joachim Deeg

  • Leukemia/Bone Marrow Transplant Program of B.C., University of British Columbia, Vancouver, Canada

    Hans-Georg Klingemann, Gordon L. Phillips

Bibliographic Information

  • Book Title: A Guide to Bone Marrow Transplantation

  • Authors: Hans Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

  • DOI: https://doi.org/10.1007/978-3-642-97077-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1988

  • Softcover ISBN: 978-3-642-97079-5Published: 28 January 2012

  • eBook ISBN: 978-3-642-97077-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VIII, 192

  • Topics: Oncology, Hematology

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