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Molecular Evolution of the Major Histocompatibility Complex

  • Conference proceedings
  • © 1991

Overview

Editors:
  1. Jan Klein

    1. Abt. Immungenetik, Max-Planck-Institut für Biologie, Tübingen, Germany

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  2. Dagmar Klein

    1. Dept. of Microbiology and Immunology, University of Miami School of Medicine, Miami, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Nato ASI Subseries H: (ASIH, volume 59)

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Table of contents (40 papers)

  1. Front Matter

    Pages I-XIII
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  2. Organization and Evolution of the MHC Chromosomal Region: An Overview

    • Corine Vernet, G. Chimini, J. Boretto, P. Le Bouteiller, P. Pontarotti
    Pages 1-11

  3. Reconstruction of Phylogenetic Trees and Evolution of Major Histocompatibility Complex Genes

    • Masatoshi Nei, Andrey Rzhetsky
    Pages 13-27

  4. Trans-Species Polymorphism of HLA Molecules, Founder Principle, and Human Evolution

    • Naoyuki Takahata
    Pages 29-49

  5. Calibrating Evolutionary Rates at Major Histocompatibility Complex Loci

    • Yoko Satta, Naoyuki Takahata, Christian Schönbach, Jutta Gutknecht, Jan Klein
    Pages 51-62

  6. Concerted Mutagenesis: Its Potential Impact on Interpretation of Evolutionary Relationships

    • Lynn S. Ripley
    Pages 63-94

  7. Two Models of Evolution of the Class I MHC

    • Austin L. Hughes
    Pages 95-101

  8. Evolution of MHC Domains: Strategy for Isolation of MHC Genes from Primitive Animals

    • Keiichiro Hashimoto, Yoshikazu Kurosawa
    Pages 103-109

  9. Generation of Allelic Polymorphism at the DRB1 Locus of Primates by Exchange of Polymorphic Domains: A Plausible Hypothesis?

    • Ulf B. Gyllensten, Mats Sundvall, Henry A. Erlich
    Pages 111-118

  10. A Phylogenetic Investigation of MHC Class II DRB Genes Reveals Convergent Evolution in the Antigen Binding Site

    • K. Gustafsson, U. Brunsberg, S. Sigurdardottir, L. Andersson
    Pages 119-130

  11. Diversification of Class II Aα Within the Genus Mus

    • Ying Ye, Jin-Xiong She, Edward K. Wakeland
    Pages 131-138

  12. Molecular and Genetic Mechanisms Involved in the Generation of Mhc Diversity

    • Jin-Xiong She, Edward K. Wakeland
    Pages 139-154

  13. Evidence for Multiple Mutational Mechanisms which Generate Polymorphism at H-2K

    • John Martinko, Khaled Girgis
    Pages 155-161

  14. Contributions of Interlocus Exchange to the Structural Diversity of the H-2K, D, and L Alleles

    • L. R. Pease, J. K. Pullen, Z. Cai, R. M. Horton
    Pages 163-170

  15. Evolution of Great Ape MHC Class I Genes

    • Z. W. Chen, A. L. Hughes, N. L. Letvin, D. I. Watkins
    Pages 171-175

  16. Evolution of New World Primate MHC Class I Genes

    • D. I. Watkins, T. L. Garber, Z. W. Chen, A. L. Hughes, N. L. Letvin
    Pages 177-191

  17. Polymorphisms of the Major Histocompatibility Complex in Old and New World Primates

    • J. Sullivan, C. Kennedy, J. Trejaut, H. Dunckley
    Pages 193-200

  18. Mhc Class II Genes of New World Monkeys and their Relationship to Human Genes

    • Blazenka Grahovac, Colm O’hUigin, Herbert Tichy, Werner E. Mayer, Jan Klein
    Pages 201-212

  19. Selective Inactivation of the Primate Mhc-DQA2 Locus

    • Marcel Kenter, Jaqueline Anholts, Gabriela Ruff, Nel Otting, Ronald Bontrop
    Pages 213-220

  20. Is DQB2 Functional Among Nonhuman Primates?

    • Lakshmi K. Gaur, Eugene R. Heise, Phillip S. Thurtle, Gerald T. Nepom
    Pages 221-229
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Keywords

About this book

From molecules to populations and back In biology, the most vigorous organisms often ensue from a union of two disparate, pure lines. In science, too, laws of hybrid vigor seem to operate at the interface between two disciplines, an interface that often proves to be fertile ground for germinating concepts and new outlooks. The fringes of research into the major histocompatibility complex (Mhc) have provided such an interface several times in the past and the encounters have invigorated fields such as transplantation biology, cellular immunology, and immunogenetics. In the last few years, a new interface has been emerging between Mhc and evolutionary genetics, and particularly the branch of evolutionary genetics dealing with molecular evolution. Mhc research relies upon molecular evolutionary genetics, with its grand superstructure of mathematical formulations, to come to grips with the events leading to and maintaining the Mhc polymorphism. Without the armament of rigorous statistical procedures developed by evolutionary geneticists, the intricate relationships among Mhc genes cannot be resolved. It will undoubtedly be a molecular geneticist who is the final arbiter in the dispute concerning the nature of the selection pressure molding the Mhc genes. And it is doubtful whether the true function of Mhc can ever be comprehended without the vantage point afforded by the elucidation of its evolutionary history.

Editors and Affiliations

  • Abt. Immungenetik, Max-Planck-Institut für Biologie, Tübingen, Germany

    Jan Klein

  • Dept. of Microbiology and Immunology, University of Miami School of Medicine, Miami, USA

    Dagmar Klein

Bibliographic Information

  • Book Title: Molecular Evolution of the Major Histocompatibility Complex

  • Editors: Jan Klein, Dagmar Klein

  • Series Title: Nato ASI Subseries H:

  • DOI: https://doi.org/10.1007/978-3-642-84622-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1991

  • Softcover ISBN: 978-3-642-84624-3Published: 15 December 2011

  • eBook ISBN: 978-3-642-84622-9Published: 29 June 2013

  • Series ISSN: 1010-8793

  • Edition Number: 1

  • Number of Pages: XIII, 509

  • Topics: Immunology, Cell Biology

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