Overview
- Editors:
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Philip L. Chambers
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Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland
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Dietrich Henschler
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Institut für Toxikologie und Pharmakologie, der Universität Würzburg, Würzburg, Germany
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Franz Oesch
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Institut für Toxikologie, der Universität Mainz, Mainz, Germany
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Table of contents (25 papers)
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Molecular Basis
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- T. R. Fox, A. M. Schumann, P. G. Watanabe
Pages 217-227
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Modifying Factors
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Front Matter
Pages 229-229
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- A. E. Rogers, H. M. Nields, P. M. Newberne
Pages 231-243
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- C. F. Hollander, C. F. A. van Bezooijen, H. A. Solleveld
Pages 244-250
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Mouse and Human Liver Tumors
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Front Matter
Pages 279-279
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Back Matter
Pages 289-295
About this book
Peroxisome proliferation in the liver parenchymal cells is frequently observed in rats and mice exposed to certain xenobiotic compounds. Hepatic peroxisome pro liferation was first noted nearly twenty years ago in the livers of rats treated with the hypolipidemic drug clofibrate (Hess et aI. , 1965; Svoboda and Azarnoff, 1966). Subsequently, several structurally unrelated hypolipidemic compounds were found to induce marked hepatomegaly and hepatic peroxisome proliferation in rats and mice, which led to the suggestion of a possible relationship between peroxisome proliferation and lipid metabolism (Reddy and Krishnakantha, 1975) as well as to the identification of a peroxisomal fatty acid f3-oxidation enzyme sys tem in the rat liver (Lazarow and DeDuve 1976). A second major class of per ox i some proliferators was identified nearly ten years ago, with the discovery that the dietary administration of a widely used phthalate-ester plasticizer di(2-ethylhex yl)phthalate (DEHP) to rats, results in the induction of peroxisomal enzymes in liver (Reddy et aL 1976a). Hypolipidemic drugs and phthalate-ester plasticizers constitute two major and important categories of chemicals with profound peroxisome proliferative property (Reddy et aL 1982; Reddy and Lalwani 1983). These two classes of xenobiotics now have important roles. First, the hypolipi demic drugs are increasingly used in the control of hyperlipidemia, a major risk factor for developing coronary heart disease.
Editors and Affiliations
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Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland
Philip L. Chambers
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Institut für Toxikologie und Pharmakologie, der Universität Würzburg, Würzburg, Germany
Dietrich Henschler
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Institut für Toxikologie, der Universität Mainz, Mainz, Germany
Franz Oesch