Overview
- Editors:
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Rony Seger
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Dept. Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
- Presents easy-to-use, comprehensive, and fully updated techniques to study MAPKs
- Serves a wide variety of scientists, from cellular biologists and biochemists to disease specialists seeking cures to diabetes, inflammation, and cancer
- Provides tips on troubleshooting difficult aspects of the included protocols
- Includes supplementary material: sn.pub/extras
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Table of contents (32 protocols)
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Structure-Function Relationships and Localization of MAP Kinases
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- Matilde Marchi, Riccardo Parra, Mario Costa, Gian Michele Ratto
Pages 287-301
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Studies on the Regulation of MAP Kinase Cascades
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Front Matter
Pages 303-303
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- Céline Tárrega, Caroline Nunes-Xavier, RocÃo Cejudo-MarÃn, Jorge MartÃn-Pérez, Rafael Pulido
Pages 305-321
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- Melissa M. McKay, Deborah K. Morrison
Pages 323-334
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- Adán Pinto, Piero Crespo
Pages 335-342
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- Shen-Hsi Yang, Andrew D. Sharrocks
Pages 343-367
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- David Gilbert, Monika Heiner, Rainer Breitling, Richard Orton
Pages 369-384
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Use of Lower Organisms, Animal Models, and Human Genetics in the Study of MAP Kinases
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Front Matter
Pages 385-385
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- Elaine A. Elion, Rupam Sahoo
Pages 387-399
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- Aharon Helman, Ze’ev Paroush
Pages 401-408
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- Gergana Galabova-Kovacs, Manuela Baccarini
Pages 421-431
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- William E. Tidyman, Katherine A. Rauen
Pages 433-447
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Study of MAP Kinases in Specific Physiological Systems
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Front Matter
Pages 449-449
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- Khadija Essafi-Benkhadir, Jacques Pouysségur, Gilles Pagès
Pages 451-469
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- Hongbo Chi, Richard A. Flavell
Pages 471-480
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- Bettina Wagner, Maria Sibilia
Pages 481-495
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- Eva M. Eves, Marsha Rich Rosner
Pages 497-505
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- Christopher J. Caunt, Stephen P. Armstrong, Craig A. McArdle
Pages 507-524
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Back Matter
Pages 525-529
About this book
Mitogen-activated protein (MAP) kinase (MAPK) cascades are key signaling components that govern essentially all cellular processes evoked by any type of stimulation, and it has been well established that the malfunctioning of these cascades leads to various diseases including cancer, autoimmunity, and diabetes. In MAP Kinase Signaling Protocols, Second Edition, expert researchers fully update the popular first edition the key techniques used in the study of MAPK signaling cascades in various cellular contexts. This thorough volume explores essential topics such as activation and function of components of the MAPK signaling cascades, the study of MAPK cascades as transmitters of membranal receptor signals, structure-function relationships of MAPKs, studies on the regulation of MAPK cascades, the use of lower organisms, animal models, and human genetics in the study of MAPKs, as well as the study of MAPKs in specific systems and diseases. Written in the highly successful Methods in Molecular Biologyâ„¢ series format, chapters includes introductions to their respective subjects, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and cutting-edge, MAP Kinase Signaling Protocols, Second Edition aims to facilitate the study of MAPKs and allow for quicker progress in our knowledge of many vital cellular processes as well as devastating diseases.
Editors and Affiliations
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Dept. Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
Rony Seger