Overview
- Editors:
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R. Angus Harkness
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Institute of Child Health, London, UK
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Gertrude B. Elion
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Burroughs Wellcome Co., Research Triangle Park, USA
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Nepomuk Zöllner
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Universität München, München, Germany
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Table of contents (106 chapters)
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Chemotherapy
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Cancer and AIDS Treatment
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- Stephen J. Clarke, Ann L. Jackman, Kenneth R. Harrap
Pages 7-13
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- Carlos J. Carrera, Lawrence D. Piro, Alan Saven, Ernest Beutler, Chihiro Terai, Dennis A. Carson
Pages 15-18
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- Ann L. Jackman, Duncan I. Jodrell, William Gibson, Trevor C. Stephens
Pages 19-23
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- R. C. Trueworthy, R. A. DeAbreu, L. H. J. Lambooy, J. P. M. Bökkerink, E. H. Stet
Pages 25-28
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- J. Balzarini, E. de Clercq
Pages 29-32
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- Kenneth L. Powell, Dorothy J. Purifoy
Pages 33-40
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Development and Effects of New Analogues
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- Richard B. Gilbertsen, Mi K. Dong, David J. Wilburn, Lynn M. Kossarek, Jagadish C. Sircar, Catherine R. Kostlan et al.
Pages 41-44
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- J. C. Sircar, C. R. Kostlan, R. B. Gilbertsen, M. K. Dong, W. A. Cetenko
Pages 45-48
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- Larry L. Bondoc Jr., Brian L. Robbins, Gurpreet S. Ahluwalia, Hiroaki Mitsuya, David G. Johns, Arnold Fridland
Pages 49-53
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- D. A. Bullough, C. Zhang, K. M. Mullane
Pages 55-55
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- Veronique W. T. Ruiz van Haperen, Gijsbert Veerman, Paul Noordhuis, Jan B. Vermorken, Godefridus J. Peters
Pages 57-60
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Analogue Effects and Metabolism
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- Pedro R. Chocair, John A. Duley, H. Anne Simmonds, J. Stewart Cameron
Pages 61-64
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- K. Ganeshaguru, W. C. P. de Mel, G. Sissolak, D. Catovsky, C. E. Dearden, A. B. Mehta et al.
Pages 65-68
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- Zvi Reiter, Osman N. Ozes, Sue Tomson, Lawrence M. Blatt, Milton W. Taylor
Pages 69-73
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- John Galivan, Myung Rhee, David G. Priest, Marlene Bunni, James H. Freisheim, John M. Whiteley
Pages 75-78
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- Hiroshi Tsutani, Daizaburo Kagawa, Michihiko Uchida, Teruo Yoshimura, Tsuneo Tanaka, Takanori Ueda et al.
Pages 79-82
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- E. H. Stet, R. A. De Abreu, Y. P. G. Janssen, J. P. M. Bökkerink, J. M. F. Trijbels
Pages 83-86
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- Ronney A. De Abreu, Frank van Strien, Lambert H. J. Lambooy, J. P. M. Bökkerink
Pages 87-91
About this book
These two volumes record the scientific and clinical work presented at the VIIth International and 3rd European joint symposium on purine and pyrimidine metabolism in man held at the Bournemouth International Conference Centre, Bournemouth, UK, from 30th June to 5th July 1991. The series of international meetings at three yearly intervals have previously been held initially in 1973 in Israel, then Austria, Spain, the Netherlands, USA and Japan. The European society for the Study of Purine and Pyrimidine Metabolism in Man (ESSPPM) which has its own executive and some finance first met in Switzerland in 1987, then in Germany in 1989. The steady evolution of the science in this series of meetings is intellectually satisfying; the subsequent clinical progress is emotionally and economically reassuring. As befits the position of purines and pyrimidines at the centre of biochemistry, there has been steady scientific development into molecular genetics and now onto developmental controls and biochemical pharmacology. The complexities of the immune system are being unravelled but an understanding of the human brain largely eludes us. Laboratory based scientists now predominate over those who work as clinical specialists in vii rheumatology, immunology, oncology and paediatrics. However, there continue to be major clinical objectives since large sections are concerned with major causes of death like ATP depletion, cancer and now AIDS; the laboratory work is providing clinical solutions.
Editors and Affiliations
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Institute of Child Health, London, UK
R. Angus Harkness
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Burroughs Wellcome Co., Research Triangle Park, USA
Gertrude B. Elion
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Universität München, München, Germany
Nepomuk Zöllner