Overview
- Editors:
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Pierre-Olivier Couraud
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Institut Cochin de Génétique Moléculaire, Paris, France
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Daniel Scherman
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CNRS-Rhône-Poulenc Rorer, Vitry sur Seine, France
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Table of contents (63 chapters)
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Blood-Brain Barrier and Drug Delivery to the Brain
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- H. S. Sharma, J. Westman, J. Cervós-Navarro, F. Nyberg
Pages 117-124
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- Evangeline Priya Eddy, Roman A. Olearchyk, Frederick M. Ryan, Timothy K. Hart, Philip L. Smith
Pages 125-136
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- Barbro B. Johansson, Irena Westergren, Claes Nordborg
Pages 137-141
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- M. P. Dehouck, B. Dehouck, L. Fenart, R. Cecchelli
Pages 143-146
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- Joachim Wegener, Helmut Franke, Stephan Decker, Martin Erben, Hans-Joachim Galla
Pages 147-152
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- Ursula Gath, Ansgar Hakvoort, H.-J. Galla
Pages 153-158
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- Z. B. Redzic, I. D. Markovic, S. S. Jovanovic, D. M. Mitrovic, Lj. M. Rakic
Pages 159-164
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- C. Videbæk, P. Ott, O. B. Paulson, G. M. Knudsen
Pages 169-170
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Multidrug Resistance P-Glycoprotein at the Blood-Brain Barrier
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- Edith Beaulieu, Michel Demeule, Diana A. Averill-Bates, Richard Béliveau
Pages 171-174
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- Delphine Lechardeur, Pierre Wils, Bertrand Schwartz, Daniel Scherman
Pages 175-183
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- A. Reichel, Z.-D. Reeve-Chen, D. J. Begley, N. J. Abbott
Pages 185-189
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- B. Joly, O. Fardel, V. Lécureur, C. Chesné, C. Puozzo, A. Guillouzo
Pages 191-196
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- Sandrine Desrayaud, Michel Lemaire
Pages 197-204
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- M. A. Barrand, K. Robertson, S. F. von Weikersthal, D. Horwell
Pages 205-207
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Signal Transduction in Brain Endothelial Cells
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- Danica B. Stanimirovic, Rita Ball, Josée Wong, Jon P. Durkin
Pages 213-220
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- Danica B. Stanimirovic, Paul Morley, Edith Hamel, Rita Ball, Geoff Mealing, Jon P. Durkin
Pages 221-227
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- Barbara Ahlemeyer, Sabine Matys, Peter Brust
Pages 229-233
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- Nobutoshi Kawai, Richard M. McCarron, Maria Spatz
Pages 235-240
About this book
The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than !50 participants. including investigators in basic neuroscience, physicians. and stu dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain.
Editors and Affiliations
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Institut Cochin de Génétique Moléculaire, Paris, France
Pierre-Olivier Couraud
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CNRS-Rhône-Poulenc Rorer, Vitry sur Seine, France
Daniel Scherman