Overview
- Editors:
-
-
Gregory Gregoriadis
-
Royal Free Hospital School of Medicine, London, UK
-
Anthony C. Allison
-
Syntex Research, Palo Alto, USA
-
George Poste
-
Smith Kline French Laboratories, Philadelphia, USA
Access this book
Other ways to access
Table of contents (23 chapters)
-
-
- Brian W. Hughes, John S. Kenney, Anthony C. Allison
Pages 203-212
-
-
-
Back Matter
Pages 233-244
About this book
Vaccination, chiefly responsible for the eradication of smallpox and the control of poliomyelitis and German measles in man and of foot-and mouth, Marek's and Newcastle disease in domestic animals, remains the best answer to infectious diseases. Early vaccines were live wild type organ isms but these have been largely replaced by attenuated or killed organisms or by purified components (subunits) thereof. More recently, developments in recombinant DNA techniques, the advent of monoclonal antibodies and progress in our understanding of the immunological structure of proteins, have laid the foundations for a new generation of vaccines. For instance, subuni t vaccines have been produced through gene cloning and a number of peptides mimicking small regions of proteins on the outer coat of viruses and capable of eliciting virus neutralizing antibodies, have been synthes ized. Such vaccines are defined at the molecular level, can elicit immune responses controlling specific infectious organisms and are, thus, potent ially free of the problems inherent in conventional ones. However, because subunit and peptide vaccines are only weakly or non-immunogenic, they re quire the presence of immunological adjuvants. These are a diverse array of agents that promote specific humoural and/or cell-mediated immunity responses to antigens. This book contains the proceedings of the 1st NATO Advanced Studies Institute "Immunological Adjuvants and Vaccines" held in Cape Sounion Beach, Greece during 24 June-5 July, 1988.
Editors and Affiliations
-
Royal Free Hospital School of Medicine, London, UK
Gregory Gregoriadis
-
Syntex Research, Palo Alto, USA
Anthony C. Allison
-
Smith Kline French Laboratories, Philadelphia, USA
George Poste