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Alcoholism: A Molecular Perspective

  • Book
  • © 1991

Overview

Editors:
  1. T. Norman Palmer

    1. The University of Western Australia, Nedlands, Perth, Australia

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Part of the book series: NATO Science Series A: (NSSA, volume 206)

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Table of contents (34 chapters)

  1. Front Matter

    Pages i-ix
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  2. Pathways of Ethanol Metabolism and Related Pathology

    • Charles S. Lieber
    Pages 1-25

  3. Regulation of Rates of Ethanol Metabolism and Liver [NAD+]/[NADH] Ratio

    • Michael J. Hardman, Rachel A. Page, Mark S. Wiseman, Kathryn E. Crow
    Pages 27-33

  4. Free Radical Pathology in Alcohol-Induced Liver Injury

    • Mario Umberto Dianzani
    Pages 35-44

  5. Free Radical Mediated Reactions and Ethanol Toxicity: Some Considerations on the Methodological Approaches

    • Emanuelle Albano, Magnus Ingelman-Sundberg, A. Tomasi, G. Poli
    Pages 45-56

  6. The Molecular Pathology of Alcoholic Liver Disease: An Overview

    • S. W. French
    Pages 57-69

  7. Acetaldehyde Adducts and Excessive Alcohol Consumption

    • Onni Niemelä
    Pages 71-75

  8. Studies of a Chemical Measure of Acetaldehyde Adduct Formation

    • Charles M. Peterson
    Pages 77-88

  9. Ethanol-Induced Phosphorylation of Cytokeratins in Primary Cultured Hepatocytes

    • Samuel W. French, H. Kawahara, M. Cadrin
    Pages 89-93

  10. Cloning and Characterization of New Alcohol Dehydrogenase and Aldehyde Dehydrogenase Isozymes

    • A. Yoshida, L. Hsu, M. Yasunami
    Pages 95-99

  11. Physiological Role of Aldehyde Dehydrogenase (EC 1.2.1.3)

    • Regina Pietruszko, Gloria Kurys, Wojciech Ambroziak
    Pages 101-106

  12. The Alcohol Dehydrogenase System in the Rat: Comparison with the Human Enzyme

    • M. Dolors Boleda, Pere Julià, Alberto Moreno, Narcís Saubi, Xavier Parés
    Pages 107-114

  13. Changes in the Inducibility of a Hepatic Aldehyde Dehydrogenase

    • P. Pappas, V. Vasiliou, M. Karageorgou, M. Marselos
    Pages 115-120

  14. Class III Alcohol Dehydrogenases: Evidence for Their Identity with the Glutathione-Dependent Formaldehyde Dehydrogenases

    • Martti Koivusalo, Lasse Uotila
    Pages 121-125

  15. Genetic Polymorphisms of Alcohol Metabolizing Enzymes and Their Significance for Alcohol-Related Problems

    • A. Yoshida
    Pages 127-138

  16. Biochemical and Genetic Studies in ALDH1-Deficient Subjects

    • Roberta Ward, Andrew Macpherson, Margaret Warren-Perry, Vibha Dave, Lily Hsu, Akira Yoshida et al.
    Pages 139-143

  17. Etiology of Subgroups in Chronic Alcoholism and Different Mechanisms in Transmitter Systems

    • O. M. Lesch, H. Walter, W. Bonte, J. Grunberger, M. Musalek, R. Sprung
    Pages 145-160

  18. Genetic Linkage Analysis: Simple Solutions for Complex Traits?

    • Luis A. Giuffra
    Pages 161-166

  19. The Changing View of Ethanol’s Actions: From Generalities to Specifics

    • Boris Tabakoff, Paula L. Hoffman
    Pages 167-174

  20. The Neurochemistry of Ethanol Tolerance

    • Boris Tabakoff, Paula L. Hoffman
    Pages 175-181
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Keywords

About this book

This book contains selected proceedings from the NATO Advanced Study Institute (AS I) "The Molecular Pathology of Alcoholism" held at the Hotel Il Ciocco in Tuscany during 26th August - 6th September 1990. Alcoholism remains one of the most challenging problems in medical care, with far-reaching medical, social and economic consequences. For example in the U. S. , estimates indicate that 18 million people have a serious drinking problem and that the total cost to the economy of alcohol abuse is $117 billion. Treatment of alcohol dependence and other alcohol-related disorders accounts for almost 15% of the total health bill of the United States. Despite the scale of the medical problem, biomedical research on alcoholism remains something of a 'Cinderella science'. Research funding from government and other bodies is relatively poor and the number of medical scientists working in the field remains small. The Organizing Committee for this NATO ASI, comprising Charles Lieber (New York), Timothy Peters (London), Mario Dianzani (Torino), Emanuele Albano (Torino) and Norman Palmer (perth, Director), were therefore particularly grateful to the NATO Scientific Affairs Division for their active support of this AS I, the first dealing with a topic related to alcohol abuse. We moreover hope that this support will continue. The theme of the ASI was an in depth discussion of the molecular events initiated by alcohol abuse that culminate in onset of alcohol-related disease.

Editors and Affiliations

  • The University of Western Australia, Nedlands, Perth, Australia

    T. Norman Palmer

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