Overview
- Editors:
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Vincenzo Zappia
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Institute of Biochemistry of Macromolecules, University of Naples, Naples, Italy
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Anthony E. Pegg
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The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, USA
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Table of contents (67 chapters)
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Metabolism of 5′ -Methylthioadenosine in Normal and Transformed Cells
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- Fulvio Della Ragione, Adriana Oliva, Massimo Fioretti, Gian Luigi Russo, Rosanna Palumbo, Vincenzo Zappia
Pages 187-197
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- John H. Fitchen, Michael K. Riscoe, Adolph J. Ferro
Pages 199-210
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- Richard L. Miller, David P. Toorchen
Pages 211-218
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- Marina Porcelli, Giovanna Cacciapuoti, Guido Cimino, Margherita Gavagnin, Guido Sodano, Vincenzo Zappia
Pages 219-228
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- Gian Luigi Russo, Fulvio Della Ragione, Riccardo Utili, Augusto Andreana, Giuseppe Ruggiero, Vincenzo Zappia
Pages 229-238
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Polyamines in Cell Growth and Differentiation
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Front Matter
Pages 239-239
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- David R. Morris, Michael W. White
Pages 241-252
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- Juhani Jänne, Leena Alhonen, Ari Hirvonen, Jarmo Wahlfors, Riitta Sinervirta, Terho Eloranta et al.
Pages 253-260
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- Lo Persson, Ingvar Holm, Louise Stjernborg, Olle Heby
Pages 261-271
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- Ajit K. Verma, J. T. Hsieh, R. C. Pong
Pages 273-290
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- Olle Heby, Lo Persson, Steven S. Smith
Pages 291-299
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- Tomas Mustelin, Tiina Pessa, Seppo Lapinjoki, Jukka Gynther, Tomi Järvinen, Terho Eloranta et al.
Pages 301-313
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- Kazuei Igarashi, Kiyoshi Ito, Yuko Sakai, Toshihiro Ogasawara, Keiko Kashiwagi
Pages 315-330
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- Heather M. Wallace, Mark E. Nuttall, Catherine S. Coleman
Pages 331-344
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- Antonio Perin, Angela Sessa, M. Alfonsina Desiderio
Pages 345-351
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- J.-Ph. Moulinoux, V. Quemener, J. Théron, R. Havouis, F. Darcel, Y. Guegan et al.
Pages 353-363
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- G. Scalabrino, M. E. Ferioli, E. Lorenzini, R. Candiani
Pages 365-378
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- Christian Löser, Ulrike Cleffmann, Frauke Alves, Ulrich R. Fölsch, Werner Creutzfeldt
Pages 379-388
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Post-Synthetic Modifications of Proteins Involving Polyamines
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Front Matter
Pages 389-389
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- Peter J. A. Davies, E. Antonio Chiocca, James P. Basilion, Susmita Poddar, Joseph P. Stein
Pages 391-401
About this book
This book contains the scientific contributions presented at an International Symposium held in Sorrento, Italy, in June 1988 under the auspices of the University of Naples, the Italian Society of Biochemistry, and the National Research Council. The modern history of polyamines dates back to 1958 when the Tabors and Rosenthal first described the outlines of their biological synthesis. From then on, and particularly in the last ten years, a veri table explosion of Literature, characterized by thousands of papers, has witnessed the interest of the scientific community toward these molecules. Perhaps the old statement that "polyamines are molecules in search of a function" is no longer true today. A large number of effects exerted by these simple molecules are well known, and in many cases the mechanisms underlying these effects have been elucidated. The first section of the volume is entirely devoted to the enzymology and molecular biology of ornithine decarboxylase. Since its discovery by Gale more than forty years ago, this can be considered among the most widely studied enzymes in biology, and one of the most complex models in enzyme regulation. The mechanism of control of the enzyme activity at the transcriptional, post-transcriptional and post-translational levels, as well as the fine regulation by antizyme, are discussed in detail. The second group of contributions deals wi th AdoMet decarboxylase, propylamine transferase, polyamine oxidase and the other enzymes related to polyamine interconversion and regeneration.
Editors and Affiliations
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Institute of Biochemistry of Macromolecules, University of Naples, Naples, Italy
Vincenzo Zappia
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The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, USA
Anthony E. Pegg