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Clinical Aspects of Neutron Capture Therapy

  • Book
  • © 1989

Overview

Editors:
  1. Ralph G. Fairchild

    1. Brookhaven National Laboratory, Upton, USA

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  2. Victor P. Bond

    1. Brookhaven National Laboratory, Upton, USA

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  3. Avril D. Woodhead

    1. Brookhaven National Laboratory, Upton, USA

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  4. Katherine Vivirito

    1. Brookhaven National Laboratory, Upton, USA

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Part of the book series: Basic Life Sciences (BLSC, volume 50)

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Table of contents (37 chapters)

  1. Computerized Axial Tomographic and Magnetic Resonance Imaging Scan Follow-up of Two Patients after Boron Neutron Capture Therapy for Glioblastoma Multiforme

    1. Computerized Axial Tomographic and Magnetic Resonance Imaging Scan Follow-up of Two Patients after Boron Neutron Capture Therapy for Glioblastoma Multiforme

      • Stephen R. Marano, John H. Spickard, Merle L. Griebenow
      Pages 153-163

  2. A Stochastic Model for High-Let Response for Boron Neutron Capture Therapy (BNCT)

    1. A Stochastic Model for High-Let Response for Boron Neutron Capture Therapy (BNCT)

      • Floyd J. Wheeler, Merle L. Griebenow, Daniel E. Wessol, David W. Nigg, Robert A. Anderl
      Pages 165-178

  3. Distributions of Sulfhydryl Borane Monomer and Dimer in Rodents and Monomer in Humans: Boron Neutron Capture Therapy of Melanoma and Glioma in Boronated Rodents

    1. Distributions of Sulfhydryl Borane Monomer and Dimer in Rodents and Monomer in Humans: Boron Neutron Capture Therapy of Melanoma and Glioma in Boronated Rodents

      • D. N. Slatkin, D. D. Joel, R. G. Fairchild, P. L. Micca, M. M. Nawrocky, B. H. Laster et al.
      Pages 179-191

  4. A Carboranyl Porphyrin for Boron Neutron Capture Therapy of Brain Tumors

    1. A Carboranyl Porphyrin for Boron Neutron Capture Therapy of Brain Tumors

      • S. B. Kahl, D. D. Joel, G. C. Finkel, P. L. Micca, M. M. Nawrocky, J. A. Coderre et al.
      Pages 193-203

  5. Distribution of a Boronated Porphyrin in Murine Tumors

    1. Distribution of a Boronated Porphyrin in Murine Tumors

      • S. B. Kahl, B. H. Laster, M.-S. Koo, L. S. Warkentien, R. G. Fairchild
      Pages 205-212

  6. Survival Assays with a Boronated Porphyrin as Measured with Hamster V-79 Cells in Culture

    1. Survival Assays with a Boronated Porphyrin as Measured with Hamster V-79 Cells in Culture

      • B. H. Laster, S. B. Kahl, E. A. Popenoe, C. Gordon, J. Kalef-Ezra, R. G. Fairchild
      Pages 213-218

  7. Neutron Capture Therapy for Melanoma

    1. Neutron Capture Therapy for Melanoma

      • Jeffrey A. Coderre, John D. Glass, Peggy Micca, Ralph G. Fairchild
      Pages 219-232

  8. Tumor-Seeking Compounds for Boron Neutron Capture Therapy: Synthesis and Biodistribution

    1. Tumor-Seeking Compounds for Boron Neutron Capture Therapy: Synthesis and Biodistribution

      • Detlef Gabel
      Pages 233-241

  9. Boron-11 Magnetic Resonance Imaging and Spectroscopy; Tools for Investigating Pharmacokinetics for Boron Neutron Capture Therapy

    1. Boron-11 Magnetic Resonance Imaging and Spectroscopy; Tools for Investigating Pharmacokinetics for Boron Neutron Capture Therapy

      • G. W. Kabalka, P. Bendel, M. Davis, D. N. Slatkin, P. L. Micca
      Pages 243-249

  10. Selective Thermal Neutron Capture Therapy and Diagnosis of Malignant Melanoma: From Basic Studies to First Clinical Treatment

    1. Selective Thermal Neutron Capture Therapy and Diagnosis of Malignant Melanoma: From Basic Studies to First Clinical Treatment

      • Yutaka Mishima, Masamitsu Ichihashi, Susumu Hatta, Chihiro Honda, Akihiro Sasase, Keizo Yamamura et al.
      Pages 251-260

  11. Workshop Summary of Moderators’ Reports

    1. Workshop Summary of Moderators’ Reports

      • Ralph G. Fairchild, Victor P. Bond, Avril D. Woodhead, Katherine Vivirito
      Pages 261-262

  12. Moderators’ Report and Discussions

    1. Moderators’ Report and Discussions

      • Ralph G. Fairchild, Victor P. Bond, Avril D. Woodhead, Katherine Vivirito
      Pages 263-276

  13. Working Group on Optimization of Radiation Dose Delivery

    1. Working Group on Optimization of Radiation Dose Delivery

      • Ralph G. Fairchild, Victor P. Bond, Avril D. Woodhead, Katherine Vivirito
      Pages 277-297

  14. Contributed Papers

    1. Blood-Brain-Barrier Impairment after Irradiation: Implication in Boron Neutron Capture Therapy

      • V. Grégoire, Andrè Keyeux, Andrè Wambersie
      Pages 299-309

    2. Implications of Genotypic and Microenvironmental Heterogeneity for the Cure of Solid Tumors by Neutron Capture Therapy

      • Sara Rockwell
      Pages 311-317

    3. Status Report on the Development of a Spallation Neutron Source for Neutron Capture Therapy (NCT)

      • H. Conde, E. Grusell, B. Larsson, E. Ramstrom, T. Ronnqvist, H. Sornsuntisook et al.
      Pages 319-323

    4. Uptake of Boron into Human Gliomas of Athymic Mice and into Syngeneic Cerebral Gliomas of Rats after Intracarotid Infusion of Sulfhydryl Boranes

      • D. D. Joel, D. N. Slatkin, P. L. Micca, M. M. Nawrocky, T. Dubois, C. Velez
      Pages 325-332

    5. Toxicities of Na2B12H11SH and Na4B24H22S2 in Mice

      • Paul G. Marshall, Marilyn E. Miller, Stanley Grand, Peggy L. Micca, Daniel N. Slatkin
      Pages 333-351

  15. Back Matter

    Pages 353-370
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Keywords

About this book

Since Locher first suggested Boron Neutron Capture Therapy (BNCT) in 1936, this theoretically ideal system has intrigued investigators. Unfortunately, the first clinical trials between 1951-1961 were not successful. However, they served to implant firmly the seed of BNCT, the growth of which has been carefully nurtured at a number of locations world-wide. This fact is attested to by the ongoing clinical trials in Japan as well as by the presence of researchers from active groups in the ten countries represented at this Workshop. In 1983 and 1985, the first and second international biannual symposia on BNCT were held, in response to a resurgence of interest in this field. In 1986, the DOE sponsored a workshop on NCT, in large part directed toward evaluating the national effort and the various neutron sources available within the United States. It now seems likely, because of various factors including improved neutron beams and boron delivery systems which have made the modality more attractive, that clinical trials will be initiated in the United States within the next few years. This 1988 special workshop, interspersed between the biannual international symposia, represents an effort to seek ideas and advice on the clinical a~pects of BNCT, from all those diverse groups with a national commitment to this project. Our purpose is to facilitate our endeavor to incorporate the best procedures and techniques in the upcoming clinical trials.

Editors and Affiliations

  • Brookhaven National Laboratory, Upton, USA

    Ralph G. Fairchild, Victor P. Bond, Avril D. Woodhead, Katherine Vivirito

Bibliographic Information

  • Book Title: Clinical Aspects of Neutron Capture Therapy

  • Editors: Ralph G. Fairchild, Victor P. Bond, Avril D. Woodhead, Katherine Vivirito

  • Series Title: Basic Life Sciences

  • DOI: https://doi.org/10.1007/978-1-4684-5622-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1989

  • Softcover ISBN: 978-1-4684-5624-0Published: 24 December 2012

  • eBook ISBN: 978-1-4684-5622-6Published: 09 March 2013

  • Edition Number: 1

  • Number of Pages: XIII, 370

  • Topics: Diagnostic Radiology

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