Overview
- Editors:
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Nandkumar S. Shah
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William S. Hall Psychiatric Institute, Department of Neuropsychiatry and Behavioral Sciences, Department of Pharmacology, University of South Carolina School of Medicine, Columbia, USA
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Alexander G. Donald
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William S. Hall Psychiatric Institute, Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina School of Medicine, Columbia, USA
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Table of contents (28 chapters)
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- Parviz Malek-Ahmadi, Michael I. Sorkin, Leonard G. Davis, Kenneth E. Callen, David Davis, Clarice A. Rieser
Pages 347-354
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- Mark S. Gold, A. Carter Pottash, Irl Extein, Frederick K. Goodwin, D. Eugene Redmond Jr., Herbert D. Kleber
Pages 355-374
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- David Pickar, Irl Extein, Philip W. Gold, Richard Summers, Dieter Naber, Frederick K. Goodwin
Pages 375-397
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- Jes Gerlach, Daniel E. Casey, Søren Korsgaard
Pages 399-406
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- L. von Knorring, F. Johansson, B. G. L. Almay
Pages 407-426
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- Jambur Ananth, Alica Bartova, Ram Rastogi
Pages 427-437
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- Toshihiro Suda, Hiroshi Demura, Reiko Demura, Kazuo Shizume, Anthony S. Liotta, Dorothy T. Krieger
Pages 439-450
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- Glenn C. Davis, Monte S. Buchsbaum, William E. Bunney Jr.
Pages 451-458
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- Nandkumar S. Shah, Donald A. Powell, Arunkumar B. Shah
Pages 459-475
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Back Matter
Pages 477-488
About this book
The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha nisms mediating the synaptic action, and to the appraisal of the involve ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux.
Editors and Affiliations
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William S. Hall Psychiatric Institute, Department of Neuropsychiatry and Behavioral Sciences, Department of Pharmacology, University of South Carolina School of Medicine, Columbia, USA
Nandkumar S. Shah
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William S. Hall Psychiatric Institute, Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina School of Medicine, Columbia, USA
Alexander G. Donald