Overview
- Editors:
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Albert H. Soloway
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The Ohio State University, Columbus, USA
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Rolf F. Barth
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The Ohio State University, Columbus, USA
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David E. Carpenter
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The Ohio State University, Columbus, USA
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Table of contents (157 chapters)
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- Y. Mishima, C. Honda, M. Ichihashi, M. Shiono, N. Wadabayashi, H. Obara et al.
Pages 705-710
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- Chihiro Honda, Masahiro Shiono, Nobutoshi Wadabayashi, Masamitsu Ichihashi, Yutaka Mishima, Kazuo Yoshino et al.
Pages 711-714
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- Giuseppe Stragliotto, Heinz Fankhauser, Patrick R. Gavin, Reto A. Meuli
Pages 715-717
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- Giuseppe Stragliotto, Daniel Schüpbach, Patrick R. Gavin, Heinz Fankhauser
Pages 719-726
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- Dietrich Haritz, Detlef Gabel, Harold Klein, René Huiskamp
Pages 727-730
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- Merja Kallio, Jaana Leppälä, Tuomo Nikula, Päivi Nikkinen, Helena Gylling, Markus Färkkilä et al.
Pages 731-733
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- Julia L. Mallesch, Douglas E. Moore, Barry J. Allen, William H. McCarthy, Robert Jones, Warwick A. Stening
Pages 735-738
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- G. Constantine, L. Dewit, R. L. Moss, B. J. Mijnheer, K. Ravensberg, F. Stecher-Rasmussen
Pages 745-748
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- R. G. Zamenhof, D. E. Wazer, J. Bernard Jr., O. K. Harling, T. A. DiPetrillo, H. Madoc-Jones et al.
Pages 749-752
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- Otto K. Harling, Ronald D. Rogus, Jean-Michel Chabeuf, Sam C. Yam, Frédérique Lambert, Jacquelyn C. Yanch et al.
Pages 753-756
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- R. Gahbauer, F. Ellis, R. Withers, G. Laramore, E. Glatstein, P. Rubin
Pages 769-774
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- Heinz Fankhauser, Patrick R. Gavin
Pages 799-805
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Back Matter
Pages 807-829
About this book
Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.