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Antibody-Drug Conjugates and Immunotoxins

From Pre-Clinical Development to Therapeutic Applications

  • Book
  • © 2013

Overview

Editors:
  1. Gail Lewis Phillips

    1. South San Francisco, USA

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  • Features up-to-date research
  • Provides an exhaustive review of anti-body drug conjugate and immunotoxin targets
  • Explores new technologies for site-specific conjugation

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (19 chapters)

  1. Antibody-Drug Conjugates for Solid Tumors

    1. Anti-PSMA Antibody-Drug Conjugates and Immunotoxins

      • Philipp Wolf
      Pages 255-272

    2. Targeting CD56 (NCAM)-Expressing Neoplasms with Lorvotuzumab Mertansine

      • John M. Lambert, James O’Leary, Kathleen R. Whiteman, Victor S. Goldmacher
      Pages 273-293

  2. Metabolism

    1. Front Matter

      Pages 295-295
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    2. Studies on the Metabolism of Antibody–Drug Conjugates

      • Xiuxia Sun, Hans Erickson
      Pages 297-316

  3. Immunotoxins

    1. Front Matter

      Pages 317-317
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    2. Design, Development, and Characterization of Recombinant Immunotoxins Targeting HER2/neu

      • Yu Cao, Michael G. Rosenblum
      Pages 319-348

    3. The Preclinical and Clinical Evaluation of VB6-845: An Immunotoxin with a De-Immunized Payload for the Systemic Treatment of Solid Tumors

      • Joycelyn Entwistle, Mark Kowalski, Jennifer Brown, Jeannick Cizeau, Glen C. MacDonald
      Pages 349-367

  4. Back Matter

    Pages 369-375
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Keywords

About this book

This volume gathers the leading research on antibody-drug conjugates and immunotoxins. Following a rigorous overview, the volume delves into focused sections on all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.

Editors and Affiliations

  • South San Francisco, USA

    Gail Lewis Phillips

Bibliographic Information

  • Book Title: Antibody-Drug Conjugates and Immunotoxins

  • Book Subtitle: From Pre-Clinical Development to Therapeutic Applications

  • Editors: Gail Lewis Phillips

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-4614-5456-4

  • Publisher: Humana New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2013

  • Hardcover ISBN: 978-1-4614-5455-7Published: 12 December 2012

  • Softcover ISBN: 978-1-4899-9700-5Published: 28 January 2015

  • eBook ISBN: 978-1-4614-5456-4Published: 13 December 2012

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: X, 378

  • Topics: Cancer Research, Biomedicine general, Antibodies

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