Overview
- Editors:
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Ira B. Black
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Cornell University Medical College, New York, USA
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Table of contents (22 chapters)
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New Neuronal Growth Factors: Session Chairman: Hans Thoenen
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- Hans Thoenen, Yves-Alain Barde, David Edgar
Pages 243-250
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- Silvio Varon, Marston Manthorpe
Pages 251-275
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Molecular Biology of Neural Development and Function: Session Chairman: Xandra O. Breakefield
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Front Matter
Pages 277-277
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- Edward Herbert, Michael Comb, Haim Rosen, Gerard Martens
Pages 279-292
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- Axel Ullrich, Alane Gray, Cara Berman, Thomas J. Dull
Pages 293-307
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- Xandra O. Breakefield, Carmela M. Castiglione, Lisa M. Coussens, Felicia B. Axelrod, Axel Ullrich
Pages 309-328
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Diseases of Development: Session Chairman: Ira B. Black
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Front Matter
Pages 329-329
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Back Matter
Pages 355-363
About this book
A central problem in neurobiology concerns mechanisms that generate the pro found diversity and specificity of the nervous system. What is the substance of diversification and specificity at the molecular, cellular, and systems levels? 4 How, for example, do 1011 neurons each form approximately 10 interconnec tions, allowing normal physiological function? How does disruption of these processes result in human disease? These proceedings represent the efforts of molecular biologists, embryologists, neurobiologists, and clinicians to approach these issues. in this volume are grouped by subject to present the varieties The chapters of methods used to approach each individual area. Section I deals with embry ogenesis and morphogenesis of the nervous system. In Chapter 3, Weston and co-workers describe the use of monoclonal antibodies that recognize specific neuronal epitopes (including specific gangliosides) for the purpose of defining heterogeneity in the neural crest, an important model system. Immunocyto chemical analysis reveals the existence of distinct sUbpopulations within the crest at extremely early stages; cells express neuronal or glial binding patterns at the time of migration. Consequently, interactions with the environment may select for predetermined populations. Le Douarin reaches similar conclusions in Chapter 1 by analyzing migratory pathways and developmental potentials in crest of quail-
Editors and Affiliations
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Cornell University Medical College, New York, USA
Ira B. Black