Overview
- Editors:
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Joel Morganroth
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Likoff Cardiovascular Institute of Hahnemann Medical College and Hospital, USA
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E. Neil Moore
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School of Veterinary Medicine, University of Pennsylvania, USA
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Table of contents (22 papers)
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Back Matter
Pages 223-234
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New Antiarrhythmic Devices
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Front Matter
Pages 235-235
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- Eric N. Prystowsky, William M. Miles, James J. Heger, Douglas P. Zipes
Pages 255-261
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- Roger A. Winkle, Debra S. Echt, R. Hardwin Mead, Vincent Gaudiani, Edward B. Stinson, Paula Schmidt
Pages 262-272
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Back Matter
Pages 279-290
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Evaluation of Atrial Arrhythmias
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Front Matter
Pages 291-291
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- John C. Somberg, Vilma Torres
Pages 315-334
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Back Matter
Pages 335-343
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Back Matter
Pages 345-356
About this book
In summary, there are many animal models that are useful in selecting new antiarrhythmic drugs. The selection of which model is most idea depends upon precisely what question is being asked. The large number of experimental models used to evaluate antiarrhythmic compounds points out the inability of anyone model to define the probability of antiarrhythmic efficacy in man. It has therefore become standard practice to utilize a batter of animal models for the evaluation of new antiarrhythmic agents. Each model has its own advantages and disadvantages and it is necessary to understand each model fully in oder to evaluate experimental findings and apply them to clinical settings. We believe that the availability of the chronic myocardial infarction ventricular tachyarrhythmia model provides 1) an excellent opportunity to more precisely understand arrhythmia mechanisms, 2) to develop new techniques such as signal averaging for evaluating late low level potentials identifying hearts at high risk of sudden death 3) to identify new antifibrillatory drugs versus drugs that are effective primarily against PVC's and ventricular tachycardia 4) to identify new surgical techniques to eliminate VT/VF, and 5) to evaluate new pacing modalities including implantable cardioverters. Although all animal models are wrong, many are very useful in furthering our knowledge directed at decreasing the distressingly high mortality from heart disease. NORMAL HtART TACHYCMDIA HtART , .. '" \ I I I I I I I I I .
Editors and Affiliations
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Likoff Cardiovascular Institute of Hahnemann Medical College and Hospital, USA
Joel Morganroth
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School of Veterinary Medicine, University of Pennsylvania, USA
E. Neil Moore