This volume presents the proceedings of the Fourth Annual Symposium on the Molecular Biology of Hemopoiesis, held in Reno, Nevada, November 1 and 2, 1988. Its focus on erythropoiesis represents an attempt to cover a rapidly expanding field, which has gone from elegant studies of erythro poietin physiology, to molecular biology, to clinical applications and again to physiology. The rapid development has been made possible by cloning of erythropoietin gene and the availability of recombinant hormone. The regulation of heme and its derivatives has also been aided by techniques of molecular biology; there is now a concerted effort to better understand how these enzymes contribute to proliferation, differentiation and maturation of the erythron. Globin gene derrangements have been targets of recent research in an attempt to correct the defect by genetic engineering. In the chapters of this book, several groups "expressed" their views on this subject. Finally, we analyze various regulators of erythropoiesis, both in vivo and in vitro. Dr. Richard Levere was a pioneer in many studies of heme metabolism and of erythropoiesis. He has been a generous supporter of research in this field and of our past meetings. It is only. fitting that this volume should be dedicated to him.
Editors and Affiliations
University of Connecticut Health Center, Farmington, USA
Joao L. Ascensao
Veterans Administration Medical Center, Reno, USA
Esmail D. Zanjani
Veterans Administration Hospital, Jackson, USA
Mehdi Tavassoli
National Heart, Lung, and Blood Institute, Bethesda, USA
Alan S. Levine
University of Nevada, Reno, USA
F. Roy MacKintosh
Bibliographic Information
Book Title: Molecular Biology of Erythropoiesis
Editors: Joao L. Ascensao, Esmail D. Zanjani, Mehdi Tavassoli, Alan S. Levine, F. Roy MacKintosh
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1989
Softcover ISBN: 978-1-4612-7897-9Published: 23 September 2011
eBook ISBN: 978-1-4613-0623-8Published: 06 December 2012