Overview
- Editors:
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Ronald T. Borchardt
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Pharmaceutical Chemistry Department, The University of Kansas, Lawrence, USA
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Cyrus R. Creveling
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NIADDK, National Institutes of Health, Bethesda, USA
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Per Magne Ueland
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Department of Pharmacology, University of Bergen, Bergen, Norway
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Table of contents (37 chapters)
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Regulation of S-Adenosylmethionine, S-Adenosylhomocysteine, and Methylthioadenosine Metabolism
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- Nicholas M. Kredich, Malak Kotb, Deborah Campano German, Craig A. Bloch
Pages 203-214
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- Robert M. Hoffman, Peter H. Stern
Pages 215-225
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- Peter K. Chiang, George A. Miura
Pages 239-251
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- Michael S. Hershfield, V. Nambi Aiyar, Sara Chaffee, Sylvia Curtis, Michael L. Greenberg
Pages 253-262
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- P. M. Ueland, A. Svardal, H. Refsum., J. R. Lillehaug, J-S. Schanche, S. Helland
Pages 263-274
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- Dennis A. Carson, E. Olavi Kajander, Carlos J. Carrera, Hisashi Yamanaka, Taizo Iizasa, Masaru Kubota et al.
Pages 275-286
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- Vincenzo Zappia, Fulvio Delia Ragione, Maria Cartenì-Farina
Pages 287-300
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- J. H. Fitchen, M. K. Riscoe, A. J. Ferro
Pages 301-312
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Clinical Aspects of S-Adenosylmethionine
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Front Matter
Pages 313-313
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- T. Bottiglieri, M. W. P. Carney, J. Edeh, M. Laundy, R. Martin, E. H. Reynolds et al.
Pages 327-338
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- Michael A. Sherer, Matthew V. Rudorfer, Giulio L. Cantoni, Robert N. Golden, William Z. Potter
Pages 339-350
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- J. R. Smythies, R. D. Alarcon, A. J. Bancroft, J. A. Monti, D. A. Morere, L. C. Tolbert et al.
Pages 351-362
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- I. Caruso, F. Montrone, M. Fumagalli, P. Sarzi, L. Boccassini, S. Santandrea et al.
Pages 363-370
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Design, Synthesis, and Biological Evaluation of Transmethylation and Inhibitors
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Front Matter
Pages 371-371
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- Janice R. Sufrin, J. B. Lombardini, Debora L. Kramer, Vitauts Alks, Ralph J. Bernacki, Carl W. Porter
Pages 373-384
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- Bradley T. Keller, Ronald T. Borchardt
Pages 385-396
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- A. Holý, I. Votruba, A. Merta, E. DeClercq, R. JelÃnek, K. Sláma et al.
Pages 397-408
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- John A. Montgomery, John A. Secrist III
Pages 409-416
About this book
This book has been developed from its earlier and far less formal presentment as the proceedings of a symposium entitled The Biochemistry of S-Adenosylmethionine as a Basis for Drug Design that was held at the Solstrand Fjord Hotel in Bergen, Norway on June 30-July 4, 1985. The purpose of the symposium was to bring together scientists from various disciplines (biochemistry, pharmacology, virology, immunology, chemistry, medicine, and so on) to discuss the recent advances that have been made in our understanding of the biological roles of S adenosylmethionine (AdoMet) and to discuss the feasibility of utilizing AdoMet-dependent enzymes as targets for drug design. Thus the information provided herein will be of value not only to basic scientists involved in elucidating the role of AdoMet in biology, but also to medicinal chemists who are using this basic knowledge in the process of drug design. The volume should also be of interest to pharmacologists and clinicians involved in biological evaluation of potential therapeutic agents arising from the efforts of the biochemists and medicinal chemists. Each plenary speaker at the symposium was requested to submit a chapter reviewing recent contributions of their discipline to our base of knowledge about the biological role of AdoMet. Topics covered in this volume include protein and phospholipid methylations (Section A), nucleic acid methyl ations (Section B), the regulation of AdoMet, S-adenosylhomocysteine, and methylthioadenosine metabolism (Section C), clinical aspects of AdoMet (Section D), and the design, synthesis, and biological evaluation of trans methylation inhibitors (Section E).
Editors and Affiliations
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Pharmaceutical Chemistry Department, The University of Kansas, Lawrence, USA
Ronald T. Borchardt
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NIADDK, National Institutes of Health, Bethesda, USA
Cyrus R. Creveling
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Department of Pharmacology, University of Bergen, Bergen, Norway
Per Magne Ueland