Overview
- Editors:
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Marc Feldmann
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Imperial Cancer Research Fund, Tumour Immunology Unit, Department of Zoology, University College London, London, UK
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Jonathan R. Lamb
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MRC Tuberculosis and Related Infections, Hammersmith Hosptial, London, UK
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James N. Woody
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Tissue Bank, Naval Medical Research Institute, Bethesda, USA
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Table of contents (40 chapters)
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Role of Cell Surface Molecules in T Cell Function
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- D. Olive, D. Charmot, P. Dubreuil, A. Tounkara, M. Ragueneau, C. Mawas et al.
Pages 173-185
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- Steven J. Mentzer, Julia L. Greenstein, Alan M. Krensky, Steven J. Burakoff
Pages 187-196
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- Nitin K. Damle, Dianne M. Fishwild, Nahid Mohagheghpour, Edgar G. Engleman
Pages 197-208
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- E. D. Zanders, M. Feldmann, K. O’Flynn, Shamshad Cockroft, J. R. Lamb
Pages 209-217
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- Alessandro Moretta, Giuseppe Pantaleo
Pages 219-225
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T Cell Clones and the Analysis of Disease
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Front Matter
Pages 227-228
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- Marco Londei, G. Franco Bottazzo, Marc Feldmann
Pages 239-250
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- J. P. De Villartay, A. Fischer, C. Griscelli
Pages 251-261
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- R. C. Gallo, M. G. Sarngadharan, J. Schupbach, M. Popovic, P. Markham, S. Z. Salahuddin et al.
Pages 263-275
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Immuneregulation
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Front Matter
Pages 277-278
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- Thomas A. Waldmann, Warren J. Leonard, Joel M. Depper, Martin Kronke, Carolyn K. Goldman, Kathleen Bongiovanni et al.
Pages 285-300
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- Marc Feldmann, E. D. Zanders, P. C. L. Beverley, J. R. Lamb
Pages 301-307
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- J. R. Lamb, Marc Feldmann, E. D. Zanders, P. C. L. Beverley
Pages 309-315
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- I. Ando, P. C. L. Beverley, D. H. Crawford, G. Hariri, M. A. Kissonerghis, M. J. Owen et al.
Pages 341-345
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Regulatory Factors Produced by T Cell Clones
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Front Matter
Pages 347-348
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- T. Kishimoto, T. Hirano, H. Kikutani, A. Muraguchi, K. Shimizu, H. Kishi et al.
Pages 349-359
About this book
Most complex biological systems, such as enzyme pathways, are effec tively controlled near the beginning of the process. There is increasing evidence that the same is true for the immune system, with the initial interactions between antigen, antigen-presenting cells, and T cells hav ing a paramount influence on the ensuing events. Thus, analysis of the early stages of the immune responses has been a preoccupation of many immunologists. This has been considerably aided by the capac ity to expand these early events, and 'immortalize' them as clones of T cells, for detailed analysis. The discovery by Morgan, Ruscetti, and Gallo (Science 193, 1007, 1976) of T-cell growth factor (now termed interleukin-2 or IL-2) has had a major impact in immunology that is far from over. The greater ease of handling murine tissues experimentally, with the availability of more precisely defined reagents such as inbred strains, has meant that, to date, most of the work on long-term T-cell cultures has been per formed in the mouse, as summarized by Fathman and Fitch (eds. , Iso lation, Characterization and Utilization of T Lymphocyte Clones, Aca demic Press, NY, 1982). However, the limitations of working with human tissues are counterbalanced by the great long-term importance of understanding disorders of human immune regulation, especially since it is becoming evident that these are far from rare. Immune deficiencies such as agammaglobulinemia and T-cell deficiencies are not common, but immune hyperresponsiveness occurring in allergy and allergiC diseases (e. g.
Editors and Affiliations
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Imperial Cancer Research Fund, Tumour Immunology Unit, Department of Zoology, University College London, London, UK
Marc Feldmann
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MRC Tuberculosis and Related Infections, Hammersmith Hosptial, London, UK
Jonathan R. Lamb
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Tissue Bank, Naval Medical Research Institute, Bethesda, USA
James N. Woody