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Signal Transduction in Mast Cells and Basophils

  • Book
  • © 1999

Overview

Editors:
  1. Ehud Razin

    1. Department of Biochemistry, Haddasah Medical School, Hebrew University, Jerusalem, Israel

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  2. Juan Rivera

    1. Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bathesda, USA

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Table of contents (29 chapters)

  1. Section III

    1. New Perspectives on Ca2+ Influx in Mast Cells

      • Michael A. McCloskey
      Pages 227-246

    2. The MAP Kinases and Their Role in Mast Cells and Basophils

      • Cheng Zhang, Michael A. Beaven
      Pages 247-273

    3. Tec Family Protein Tyrosine Kinases and Their Interaction with Protein Kinase C

      • Toshiaki Kawakami, Libo Yao, Yuko Kawakami
      Pages 274-285

    4. Activation of Heterotrimeric GTP-Binding Proteins

      • Ronit Sagi-Eisenberg
      Pages 286-299

    5. Activation of Small GTP-Binding Proteins

      • Anna Koffer, Richard Sullivan
      Pages 300-315

  2. Section IV

    1. Front Matter

      Pages 317-317
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    2. Regulation of Mediator Synthesis and Secretion: Overview

      • Richard L. Stevens
      Pages 319-322

    3. Early-Response Genes in Mast Cell Activation

      • Hovav Nechushtan, Ehud Razin
      Pages 323-327

    4. FcεRI-Mediated Activation of NF-AT

      • Thomas Baumruker, Eva E. Prieschl
      Pages 328-336

    5. Regulation of IL-4 Expression in Mast Cells

      • Melanie A. Sherman, Melissa A. Brown
      Pages 337-349

    6. Arachidonic Acid Metabolism in Mast Cells

      • Clifton O. Bingham III, Jonathan P. Arm, K. Frank Austen
      Pages 350-361

    7. Role of ICRAC in the Regulation of Secretion

      • Chris Mathes, Francisco Mendez, Andrea Fleig, Reinhold Penner
      Pages 362-371

    8. Regulation of Secretion in Human Basophils

      • Donald MacGlashan Jr.
      Pages 372-389

    9. Histamine Releasing Factors

      • Susan M. MacDonald
      Pages 390-401

  3. Back Matter

    Pages 403-423
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Keywords

About this book

Mast cells and basophils are responsible for inflammatory and allergic reactions. As such, the signals that generate these responses and how their pathways of action work are the focus of much present day research into allergy and inflammation. This book focuses primarily on the molecular mechanisms that govern mast cell and basophil cell biology and function, as well as providing a comprehensive summary of the field of signal transduction and also giving insights into areas that have therapeutic potential. The book provides detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide the reader with an up-to-date account of a topic where the rapid progress makes conventional information gathering difficult.

Editors and Affiliations

  • Department of Biochemistry, Haddasah Medical School, Hebrew University, Jerusalem, Israel

    Ehud Razin

  • Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bathesda, USA

    Juan Rivera

Bibliographic Information

  • Book Title: Signal Transduction in Mast Cells and Basophils

  • Editors: Ehud Razin, Juan Rivera

  • DOI: https://doi.org/10.1007/978-1-4612-2154-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York, Inc. 1999

  • Hardcover ISBN: 978-0-387-98625-8Published: 11 May 1999

  • Softcover ISBN: 978-1-4612-7435-3Published: 30 September 2011

  • eBook ISBN: 978-1-4612-2154-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XX, 423

  • Topics: Life Sciences, general, Cell Biology, Immunology

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