Overview
- Editors:
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Jonathan J. Li
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Division of Etiology & Prevention of Hormonal Cancers Kansas Cancer Intitute, University of Kansas Medical Center, Kansas City, USA
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Sara Antonia Li
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Division of Etiology & Prevention of Hormonal Cancers Kansas Cancer Intitute, University of Kansas Medical Center, Kansas City, USA
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Janet R. Daling
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Division of Public Health Sciences Fred Hutchinson Cancer Research Center, University of Washington, Seattle, USA
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Table of contents (59 papers)
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Estrogen/Progesterone-Breast Cancer
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- Satyabrata Nandi, Raphael C. Guzman, Jason Yang, Lakshmanaswamy Rajkumar, Gudmundur Thordarson
Pages 161-165
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- Sara Antonia Li, Joshua DeZhong Liao, Jonathan J. Li
Pages 178-188
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- Kristen L. Murphey, Jeffrey M. Rosen
Pages 189-197
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Cell Cycle, Cell Proliferation
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Front Matter
Pages 199-199
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- Richard P. DiAugustine, Diane M. Klotz, R. Gregg Richards
Pages 201-205
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- Valeria Belsito Petrizzi, Luigi Cicatiello, Lucia Altucci, Raffaele Addeo, Raphaelle Borgo, Massimo Cancemi et al.
Pages 206-219
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- Owen W. J. Prall, Eileen M. Rogan, Elizabeth A. Musgrove, Colin K. W. Watts, Robert L. Sutherland
Pages 220-227
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Oncogenes/Tumor Suppressor Genes
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Front Matter
Pages 229-229
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- R. P. C. Shiu, D. Dubik, M. Venditti, J. Sparling, B. Iwasiow, P. H. Watson
Pages 231-237
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- Salman M. Hyder, Holly L. Boettger-Tong, Sari Mäkelä, George M. Stancel
Pages 238-249
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- Thomas C. Spelsberg, Malayannan Subramaniam, Katrina M. Waters, Theresa E. Hefferan, David J. Rickard, Gregory G. Reinholz
Pages 250-260
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Aromatase: Implications for Breast Cancer
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Front Matter
Pages 261-261
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- Shiuan Chen, Dujin Zhou, Yeh-Chih Kao, Chun Yang, Baiba Grube
Pages 267-276
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- A. Singh, A. Purohit, M. W. Ghilchik, M. J. Reed
Pages 277-284
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- Robert W. Brueggemeier, Anne L. Quinn, Yasuro Sugimoto, Young C. Lin, Michelle L. Parrett, Farahnaz S. Joarder et al.
Pages 285-298
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Organ Site: Prostate/Ovary
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Front Matter
Pages 299-299
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- Shutsung Liao, John M. Kokontis, Richard A. Hiipakka
Pages 301-306
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About this book
Since our previous symposium in 1995, the pace of research in hormones and cancer has accelerated. Progress in our understanding of hormonal carcinogenic processes has been a direct result of the advances made in cell biology, endocrinology, and carcinogenesis at the molecular level. The newer fields of molecular genetics and cytogenetics already have and are expected to continue to playa major role in furthering our understanding of the cellular and molecular events in hormonal carcinogenesis. It has become increasingly clear that the risk of naturally occurring sex hormones in carcinogenic processes, both in human and in animal models, requires only minute quantities of hormones, at both the serum and tissue levels. Moreover, hormone target tissues for neoplastic transformation, perhaps with the exception of the liver, generally have relatively modest ability to metabolize sex hormones, such as the breast and prostate. Table 1 summarizes the serum, and in most cases, the tissue levels of sex hormones, both endogenously and exogenously ingested, which are associated with increased risk for endocrine-associated cancers such as breast, endometrium, and prostate, as well as the hormone levels of four experimental models that have been shown to elicit high tumor incidences. In contrast to the human, in which the hormone levels are cyclic, however, the latter require continuous hormone exposure at these relatively low levels.