Overview
- Editors:
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Kary B. Mullis
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La Jolla, USA
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François Ferré
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The Immune Response Corporation, Carlsbad, USA
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Richard A. Gibbs
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Institute for Molecular Genetics, Baylor College of Medicine, Houston, USA
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Table of contents (35 chapters)
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Methodology
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Sequencing
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- André Rosenthal, Matthias Platzer, D. Stephen Charnock-Jones
Pages 222-229
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Applications
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Front Matter
Pages 231-231
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General Applications
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- Craig Tuerk, Sheela MacDougal-Waugh, Gerald Z. Hertz, Larry Gold
Pages 233-243
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- Bruce Budowle, Antti Sajantila, Manfred N. Hochmeister, Catherine T. Comey
Pages 244-256
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- Matthias Höss, Oliva Handt, Svante Pääbo
Pages 257-264
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Genetic Analysis
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- Didier Montarras, Christian Pinset, Jamel Chelly, Axel Kahn
Pages 277-294
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- John Welsh, Michael McClelland
Pages 295-303
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- Bruno W. S. Sobral, Rhonda J. Honeycutt
Pages 304-319
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Assessment of Therapy Effectiveness
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- Stephen P. Hunger, Michael L. Cleary
Pages 323-334
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- Luc d’Auriol, François Sigaux
Pages 335-343
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- Richard A. Morgan, W. French Anderson
Pages 357-366
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Diagnostics
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- Belinda J. F. Rossiter, C. Thomas Caskey
Pages 395-405
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PCR and the World of Business
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Front Matter
Pages 419-419
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Back Matter
Pages 442-458
About this book
James D. Watson When, in late March of 1953, Francis Crick and I came to write the first Nature paper describing the double helical structure of the DNA molecule, Francis had wanted to include a lengthy discussion of the genetic implications of a molecule whose struc ture we had divined from a minimum of experimental data and on theoretical argu ments based on physical principles. But I felt that this might be tempting fate, given that we had not yet seen the detailed evidence from King's College. Nevertheless, we reached a compromise and decided to include a sentence that pointed to the biological significance of the molecule's key feature-the complementary pairing of the bases. "It has not escaped our notice," Francis wrote, "that the specific pairing that we have postulated immediately suggests a possible copying mechanism for the genetic material." By May, when we were writing the second Nature paper, I was more confident that the proposed structure was at the very least substantially correct, so that this second paper contains a discussion of molecular self-duplication using templates or molds. We pointed out that, as a consequence of base pairing, a DNA molecule has two chains that are complementary to each other. Each chain could then act ". . . as a template for the formation on itself of a new companion chain, so that eventually we shall have two pairs of chains, where we only had one before" and, moreover, " ...
Editors and Affiliations
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La Jolla, USA
Kary B. Mullis
-
The Immune Response Corporation, Carlsbad, USA
François Ferré
-
Institute for Molecular Genetics, Baylor College of Medicine, Houston, USA
Richard A. Gibbs