Overview
This book will discuss recent progress in innate immunity and Treg cells
This book will discuss the regulation of innate immunity through Toll-like receptor (TLR) signaling
Additionally, this book will offer an overview of recent developments in topics of cancer immunotherapy
Includes supplementary material: sn.pub/extras
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Table of contents (24 chapters)
Keywords
About this book
Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.
Editors and Affiliations
Bibliographic Information
Book Title: Innate Immune Regulation and Cancer Immunotherapy
Editors: Rongfu Wang
DOI: https://doi.org/10.1007/978-1-4419-9914-6
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media, LLC 2012
Hardcover ISBN: 978-1-4419-9913-9Published: 01 December 2011
Softcover ISBN: 978-1-4899-8590-3Published: 24 November 2014
eBook ISBN: 978-1-4419-9914-6Published: 02 February 2012
Edition Number: 1
Number of Pages: X, 478
Topics: Cancer Research, Immunology, Pharmacology/Toxicology