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Epigenomics

Methods and Protocols

  • Book
  • © 2023

Overview

Editors:
  1. Izuho Hatada

    1. Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan

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    You can also search for this editor in PubMed   Google Scholar

  2. Takuro Horii

    1. Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2577)

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Table of contents (20 protocols)

  1. Manipulation of the Epigenome: Inducible System for Epigenome Editing

    1. A Split CRISPR–Cpf1 Platform for Inducible Gene Activation

      • Takahiro Otabe, Yuta Nihongaki, Moritoshi Sato
      Pages 229-240

  2. Manipulation of the Epigenome: Epigenetically Modified Animals

    1. Front Matter

      Pages 241-241
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    2. Targeted DNA Methylation in Mouse Early Embryos

      • Taiga Yamazaki, Yu Hatano, Noritada Kobayashi, Kazuo Yamagata
      Pages 243-254

    3. Generation of Epigenetic Disease Model Mice by Targeted Demethylation of the Epigenome

      • Takuro Horii, Sumiyo Morita, Izuho Hatada
      Pages 255-268

    4. In Vivo Tissue-Specific DNA Demethylation in Mouse Liver Through a Hydrodynamic Tail Vein Injection

      • Koshi Hashimoto, Nozomi Hanzawa
      Pages 269-277

    5. Targeted Manipulation of Histone Modification in Medaka Embryos

      • Hiroto S. Fukushima, Hiroyuki Takeda, Ryohei Nakamura
      Pages 279-293

  3. Back Matter

    Pages 295-296
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Keywords

About this book

This detailed volume provides a comprehensive collection of protocols for epigenomic research, powering our ability to analyze epigenetic modifications across the entire genome. Beginning with methods used to investigate epigenomic modifications such as DNA methylation, histone modifications, and chromatin structure, the book continues with methods for manipulating the epigenome, including platforms for epigenome editing, inducible systems for epigenome editing, and epigenetically modified animals. Written for the highly successful Methods in Molecular Biology series, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Epigenomics: Methods and Protocols serves as an ideal resource for researchers looking to further expand the utility and scope of epigenomics research.

Editors and Affiliations

  • Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan

    Izuho Hatada, Takuro Horii

Bibliographic Information

  • Book Title: Epigenomics

  • Book Subtitle: Methods and Protocols

  • Editors: Izuho Hatada, Takuro Horii

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-2724-2

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2023

  • Hardcover ISBN: 978-1-0716-2723-5Published: 30 September 2022

  • Softcover ISBN: 978-1-0716-2726-6Published: 02 October 2023

  • eBook ISBN: 978-1-0716-2724-2Published: 29 September 2022

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 296

  • Number of Illustrations: 11 b/w illustrations, 64 illustrations in colour

  • Topics: Genetics and Genomics, Biological Techniques

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