Overview
- Editors:
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Dolph L. Hatfield
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National Cancer Institute, USA
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Marla J. Berry
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University of Hawaii, USA
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Vadim N. Gladyshev
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Univeristy of Nebraska, USA
Features the many new discoveries have occurred since the 1st edition on Selenium was published in 2001
New investigators who have made important contributions to the field have been added as chapter authors
Includes supplementary material: sn.pub/extras
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Table of contents (35 chapters)
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Selenium-containing proteins
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- Marcus Conrad, Georg W. Bornkamm, Markus Brielmeier
Pages 195-206
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- Antonio C. Bianco, P. Reed Larsen
Pages 207-219
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- Linda Johansson, Elias S. J. Arnér
Pages 221-230
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Selenium and human health
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Front Matter
Pages 231-231
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- Ulrich Schweizer, Lutz Schomburg
Pages 233-248
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- Gerald F. Combs Jr., Junxuan Lü
Pages 249-264
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- Ke Zu, Yue Wu, Young-Mee Park, Clement Ip
Pages 265-276
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- Alan M. Diamond, Rhonda L. Brown
Pages 277-286
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- Marianna K. Baum, Adriana Campa
Pages 299-310
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- Roderick C. McKenzie, Geoffrey J. Beckett, John R. Arthur
Pages 311-322
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- Matilde Maiorino, Antonella Roveri, Fulvio Ursini, Regina Brigelius-Flohé, Leopold Flohé
Pages 323-331
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- Bradley A. Carlson, Xue-Ming Xu, Rajeev Shrimali, Aniruddha Sengupta, Min-Hyuk Yoo, Nianxin Zhong et al.
Pages 333-341
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- Cristina Pallarès, Florenci Serras, Montserrat Corominas
Pages 343-353
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- Gustavo Salinas, Alexey V. Lobanov, Vadim N. Gladyshev
Pages 355-366
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- Cindy D. Davis, John A. Milner
Pages 367-378
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- Ick Young Kim, Tae Soo Kim, Youn Wook Chung, Daewon Jeong
Pages 379-385
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- Orville A. Levander, Raymond F. Burk
Pages 399-410
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Back Matter
Pages 411-419
About this book
The discovery of selenoproteins in 1973 was the starting point for today's flourishing selenium field [1,2]. It provided evidence that selenium had biochemical functions that could account for its nutritional effects [3,4]. Further, it opened the selenium field to investigation by the methods of biochemistry, which led to the identification of several more selenoproteins and showed that selenocysteine was the form of the element in animal selenoproteins and in most bacterial ones. Although noteworthy efforts were made to uncover the mechanism of selenocysteine and selenoprotein synthesis using biochemical methods, the problem yielded only when attacked with the methods of molecular biology [5,6]. The bacterial mechanism was characterized first; characterization of the animal mechanism is a work in progress. It is interesting to note that the only genes that are devoted to selenium metabolism are those that support selenoprotein synthesis and selenocysteine catabolism. Consequently, it seems likely that competition for selenium between selenoprotein synthesis and the production of selenium excretory metabolites [7] controls who- body selenium homeostasis. The physiological functions of selenium derive fi-om the catalytic and physical properties of selenoproteins. Selenoproteins such as the glutathione peroxidases and the thioredoxin reductases have redox activities that allow them to serve in oxidant defense. The deiodinases use their redox activities to activate and inactivate thyroid hormones. From these two examples, it can be seen that selenoprotein functions are diverse while having in common a redox mechanism.
Editors and Affiliations
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National Cancer Institute, USA
Dolph L. Hatfield
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University of Hawaii, USA
Marla J. Berry
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Univeristy of Nebraska, USA
Vadim N. Gladyshev