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The Pharmacology of Pain

  • Book
  • © 1997

Overview

Editors:
  1. A. Dickenson

    1. Department of Pharmacology, University College London, London, UK

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  2. J.-M. Besson

    1. Physiopharmacologie du Système Nerveux et Laboratioire de Physiopharmacologie de la Douluer (EPHE), INSERM, U.161, Paris, France

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 130)

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Table of contents (16 chapters)

  1. Front Matter

    Pages I-XXII
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  2. Animal Models of Analgesia

    • A. Tjølsen, K. Hole
    Pages 1-20

  3. Peripheral Mediators of Pain

    • A. Dray
    Pages 21-41

  4. Non-steroidal Anti-inflammatory Drugs and Pain

    • I. Appleton
    Pages 43-60

  5. The Sympathetic Nervous System and Pain

    • M. Koltzenburg
    Pages 61-91

  6. Excitability Blockers: Anticonvulsants and Low Concentration Local Anesthetics in the Treatment of Chronic Pain

    • H. L. Fields, M. C. Rowbotham, M. Devor
    Pages 93-116

  7. Tachykinins: Central and Peripheral Effects

    • P. J. Birch
    Pages 117-133

  8. Growth Factors and Pain

    • S. B. McMahon, D. L. H. Bennett
    Pages 135-165

  9. Mechanisms of Central Hypersensitivity: Excitatory Amino Acid Mechanisms and Their Control

    • A. Dickenson
    Pages 167-210

  10. Novel Modulators in Nociception

    • X.-J. Xu, Z. Wiesenfeld-Hallin
    Pages 211-234

  11. Pharmacological Studies of Nociceptive Systems Using the C-Fos Immunohistochemical Technique: An Indicator of Noxiously Activated Spinal Neurones

    • V. Chapman, J.-M. Besson
    Pages 235-279

  12. Molecular Aspect of Opioid Receptors

    • B. L. Kieffer
    Pages 281-303

  13. Opioid Pharmacology of Acute and Chronic Pain

    • M. H. Ossipov, T. P. Malan Jr., J. Lai, F. Porreca
    Pages 305-333

  14. Opioid Problems, and Morphine Metabolism and Excretion

    • H. J. McQuay, R. A. Moore
    Pages 335-360

  15. Inhibitory Neurotransmitters and Nociception: Role of GABA and Glycine

    • D. L. Hammond
    Pages 361-383

  16. The Role of Descending Noradrenergic and Serotoninergic Pathways in the Modulation of Nociception: Focus on Receptor Multiplicity

    • M. J. Millan
    Pages 385-446

  17. Neonatal Pharmacology of Pain

    • M. Fitzgerald
    Pages 447-465

  18. Back Matter

    Pages 467-479
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Keywords

About this book

Pain is a symptom of many clinical disorders, afflicts a large proportion of the population and is largely treated by pharmacological means. However, the two main classes of drugs used are the opioids and the non-steroidal anti­ inflammatory drugs, drugs that have a long history. The last decade has seen remarkable advances in our understanding of some of the pharmacological bases of pain and analgesia and this book aims to reflect these rapid changes in our understanding of pain mechanisms. One impetus to these scientific advances has been dialogue and interactions between scientists and clinicians; as a result we now has a number of animal models of clinical pain states, to mimic certain aspects of clinical pathophysiological pain states. Molecular aspects of receptors and the synthesis of tools for probing receptor function have also been rapid growth areas. A number of controlled clinical studies using novel licensed drugs have also resulted from recent research, offering hope to certain patients with severe intractable pain. However, we desperately need the pharmaceutical industry to develop new drugs based on these novel targets for analgesic therapy. This book attempts to provide an overview of the important areas of the pharmacology of pain. This book, although providing an account of the pharmacology of pain transmission and its control based on the underlying anatomical organization and physiological responses, does not attempt to cover these latter two areas.

Editors and Affiliations

  • Department of Pharmacology, University College London, London, UK

    A. Dickenson

  • Physiopharmacologie du Système Nerveux et Laboratioire de Physiopharmacologie de la Douluer (EPHE), INSERM, U.161, Paris, France

    J.-M. Besson

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