Overview
- Editors:
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Pierre-Olivier Couraud
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Institut Cochin de Génétique Moléculaire, Paris, France
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Daniel Scherman
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CNRS-Rhône-Poulenc Rorer, Vitry sur Seine, France
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Table of contents (63 chapters)
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Physiological Transports through the Blood-Brain Barrier
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- Richard F. Keep, Walter Stummer, Jianming Xiang, A. Lorris Betz
Pages 11-16
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- P. J. Gaillard, A. G. De Boer, D. D. Breimer
Pages 17-19
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- A. Reichel, D. J. Begley, A. Ermisch
Pages 21-26
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- Hameed Al-Sarraf, Kevin A. Smart, Malcolm B. Segal, Jane E. Preston
Pages 27-33
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- Ivanka D. Markovic, Zoran B. Redzic, Suzana S. Jovanovic, Dusan M. Mitrovic, Ljubisa M. Rakic
Pages 35-39
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- S. S. Jovanovic, Z. B. Redzic, I. D. Markovic, D. M. Mitrovic, Lj. M. Rakic
Pages 41-45
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- Richard F. Keep, Jianming Xiang, A. Lorris Betz
Pages 47-50
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- Laurence Descamps, Marie-Pierre Dehouck, Gérard Torpier, Roméo Cecchelli
Pages 51-54
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- H. S. Sharma, K. Sanderson, E.-L. Glämsta, Y. Olsson, F. Nyberg
Pages 63-68
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- Sarah A. Williams, Thomas J. Abbruscato, Lajos Szabo, Robin Polt, Victor Hruby, Thomas P. Davis
Pages 69-77
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- Holger Gerhardt, Stefan Liebner, Hartwig Wolburg
Pages 79-81
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Blood-Brain Barrier and Drug Delivery to the Brain
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- Kenneth R. Davies, Grace Richardson, Wendy Akmentin, Virgil Acuff, Joseph D. Fenstermacher
Pages 83-91
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- Uwe Kniesel, Werner Risau, Hartwig Wolburg
Pages 93-95
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- Bernhard J. Tewes, Hans-Joachim Galla
Pages 97-101
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- Andrea Hoffmann, Eckart Grabenhorst, Manfred Nimtz, Harald S. Conradt
Pages 103-107
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- P. Brust, S. Matys, J. Wober, A. Friedrich, R. Bergmann, B. Ahlemeyer
Pages 109-115
About this book
The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than !50 participants. including investigators in basic neuroscience, physicians. and stu dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain.
Editors and Affiliations
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Institut Cochin de Génétique Moléculaire, Paris, France
Pierre-Olivier Couraud
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CNRS-Rhône-Poulenc Rorer, Vitry sur Seine, France
Daniel Scherman