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Radioimmunoassay in Basic and Clinical Pharmacology

  • Book
  • © 1987

Overview

Editors:
  1. Carlo Patrono

    1. Institute of Pharmacology, Catholic University of the Sacred Heart, Rome, Italy

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  2. Bernhard A. Peskar

    1. Institute of Pharmacology and Toxicology, Ruhr-University Bochum Im Lottental, Bochum 1, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 82)

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Table of contents (24 chapters)

  1. Front Matter

    Pages I-XXII
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  2. Radioimmunoassay: Historical Aspects and General Considerations

    • R. S. Yalow
    Pages 1-6

  3. Basic Principles of Antigen-Antibody Interaction

    • F. Celada
    Pages 7-22

  4. Production of Antisera by Conventional Techniques

    • G. Ciabattoni
    Pages 23-68

  5. Production of Monoclonal Antibodies for Radioimmunoassays

    • K. Brune, M. Reinke
    Pages 69-89

  6. Radioiodination and Other Labeling Techniques

    • J. Grassi, J. Maclouf, P. Pradelles
    Pages 91-141

  7. Strategies for Developing Specific and Sensitive Hapten Radioimmunoassays

    • E. Ezan, S. Mamas, C. Rougeot, F. Dray
    Pages 143-179

  8. How to Improve the Sensitivity of a Radioimmunoassay

    • G. Ciabattoni
    Pages 181-191

  9. Statistical Aspects of Radioimmunoassay

    • D. Rodbard, V. Guardabasso, P. J. Munson
    Pages 193-212

  10. Validation Criteria for Radioimmunoassay

    • C. Patrono
    Pages 213-225

  11. Measurement of Opioid Peptides in Biologic Fluids by Radioimmunoassay

    • F. Nyberg, I. Christensson-Nylander, L. Terenius
    Pages 227-253

  12. Radioimmunoassay of Pituitary and Hypothalamic Hormones

    • D. Cocchi
    Pages 255-290

  13. Radioimmunoassay of Nonpituitary Peptide Hormones

    • G. Nilsson
    Pages 291-314

  14. Radioimmunoassay of Gastrointestinal Polypeptides

    • J. H. Walsh, H. C. Wong
    Pages 315-350

  15. Radioimmunoassay of Atrial Peptide Blood and Tissue Levels

    • M. L. Michener, D. Schwartz, M. G. Currie, D. M. Geller, P. Needleman
    Pages 351-362

  16. Immunochemical Methods for Adrenal and Gonadal Steroids

    • M. Pazzagli, M. Serio
    Pages 363-400

  17. Radioimmunoassay of Thyroid Hormones

    • L. Bartalena, S. Mariotti, A. Pinchera
    Pages 401-431

  18. Radioimmunoassay of Catecholamines

    • E. Knoll, H. Wisser
    Pages 433-448

  19. Radioimmunoassay of Prostaglandins and Other Cyclooxygenase Products of Arachidonate Metabolism

    • B. A. Peskar, Th. Simmet, B. M. Peskar
    Pages 449-480

  20. Radioimmunoassay of Leukotrienes and Other Lipoxygenase Products of Arachidonate

    • H. J. Zweerink, G. A. Limjuco, E. C. Hayes
    Pages 481-500
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Keywords

About this book

Thirty years have elapsed since the first description by S. A. BERSON and R. S. Y ALOW of the basic principles of radioimmunoassay (RIA). During this period of time, RIA methodology has been instrumental to the growth of many areas of biomedical research, including endocrinology, oncology, hematology, and pharmacology. It has done so by providing a relatively simple universal tool allowing, for the first time, the detection of endogenous mediators that are present 12 10 in body fluids at concentrations as low as 10- _10- M. The fundamental nature of this discovery and the wide-ranging fall-out of basic and clinical knowledge derived from its application have been acknowledged by the many honors tributed to its pioneers, including the Nobel Prize awarded to Dr. Y ALOW 10 years ago. Although several excellent books have been published during the past decades covering various aspects of RIA methodology, we felt the need, as pharmacologists, for a comprehensive discussion of the methodological and conceptual issues related to the main classes of mediators of drug action and to drugs themselves. Thus, we gladly accepted the challenge provided by the invitation to edit a volume of the Handbook of Experimental Pharmacology on Radioimmunoassay in Basic and Clinical Pharmacology. We tried to balance the emphasis placed on more general aspects of the RIA methodology and that on specific mediators.

Editors and Affiliations

  • Institute of Pharmacology, Catholic University of the Sacred Heart, Rome, Italy

    Carlo Patrono

  • Institute of Pharmacology and Toxicology, Ruhr-University Bochum Im Lottental, Bochum 1, Germany

    Bernhard A. Peskar

Bibliographic Information

  • Book Title: Radioimmunoassay in Basic and Clinical Pharmacology

  • Editors: Carlo Patrono, Bernhard A. Peskar

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-71809-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1987

  • Softcover ISBN: 978-3-642-71811-3Published: 18 November 2011

  • eBook ISBN: 978-3-642-71809-0Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXII, 611

  • Topics: Pharmacology/Toxicology, Metabolic Diseases, Pharmacy

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