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Antiepileptic Drugs

  • Book
  • © 1985

Overview

Editors:
  1. Hans-Hasso Frey

    1. Laboratorium für Pharmakologie und Toxikologie Fachbereich Veterinärmedizin, Freie Universität Berlin, Germany

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  2. Dieter Janz

    1. Abteilung für Neurologie, Klinikum Charlottenburg, Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 74)

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Table of contents (28 chapters)

  1. Front Matter

    Pages I-XXII
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  2. Clinical Aspects of Epileptic Disease

    1. Front Matter

      Pages 1-1
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    2. Epilepsy: Seizures and Syndromes

      • D. Janz
      Pages 3-34

    3. Electroencephalography

      • R. Hess
      Pages 35-54

    4. Epilepsy in Animals

      • T. A. Holliday
      Pages 55-76

  3. Pathophysiology of Seizure Disorders

    1. Front Matter

      Pages 77-77
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    2. Intermediary Metabolism

      • B. E. Dwyer, C. G. Wasterlain
      Pages 79-100

    3. Monoamines and the Pathophysiology of Seizure Disorders

      • E. Przegaliński
      Pages 101-137

    4. Acetylcholine

      • C. Bianchi, L. Beani
      Pages 139-151

    5. GABA and Other Amino Acids

      • B. S. Meldrum
      Pages 153-188

    6. Prostaglandins

      • K. Wiśniewski, H.-H. Frey
      Pages 189-195

  4. General Pharmacology of Antiepileptic Drugs

    1. Front Matter

      Pages 197-197
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    2. Chemical Constitution and Pharmacological Effect

      • H. Schäfer
      Pages 199-243

    3. Biochemistry

      • G. L. Jones, D. M. Woodbury
      Pages 245-263

    4. Tolerance and Dependence

      • H.-H. Frey
      Pages 265-282

    5. Animal Experimental Methods in the Study of Antiepileptic Drugs

      • W. P. Koella, G. D. Gladding, H. J. Kupferberg, E. A. Swinyard
      Pages 283-347

  5. Specific Pharmacology of Antiepileptic Drugs

    1. Front Matter

      Pages 349-349
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    2. Hydantoins

      • G. L. Jones, G. H. Wimbish
      Pages 351-419

    3. Barbituric Acid Derivatives

      • B. B. Gallagher, L. S. Freer
      Pages 421-447

    4. Primidone

      • H.-H. Frey
      Pages 449-477
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Keywords

About this book

Epileptic disorders need treatment for many years or even for life, and this makes a thorough understanding of the pharmacokinetics and possible hazards and side effects of the drugs used in treatment mandatory. During recent decades our knowledge in this field has considerably increased, not least as a result of the development of specific and sensitive methods for the determination of anti­ epileptic agents in biological material. The clinical pharmacology of this group of drugs has been studied extensively and can today be regarded as well established. This does not necessarily mean that drug treatment of epilepsy is without problems. For example, it has recently been shown that one of the newer anti­ epileptic drugs, greeted with great enthusiasm by clinicians, may in rare instances induce serious damage to the liver and the pancreas, and seems even to have a certain teratogenic potential. Clinical problems should be understood as a challenge to the experimental pharmacologist, who should try to find explanations for the clinical hazards, and, if possible, show new ways in which better drugs might be developed. In recent years interest has focused on the importance of the inhibitory transmitter 'l'-aminobutyric acid (GABA) in the pathophysiology of epilepsy, and there have been a series of attempts to find useful antiepileptic drugs among substances interfering with GABA metabolism in the CNS.

Editors and Affiliations

  • Laboratorium für Pharmakologie und Toxikologie Fachbereich Veterinärmedizin, Freie Universität Berlin, Germany

    Hans-Hasso Frey

  • Abteilung für Neurologie, Klinikum Charlottenburg, Germany

    Dieter Janz

Bibliographic Information

  • Book Title: Antiepileptic Drugs

  • Editors: Hans-Hasso Frey, Dieter Janz

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-69518-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1985

  • Softcover ISBN: 978-3-642-69520-9Published: 06 December 2011

  • eBook ISBN: 978-3-642-69518-6Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXII, 867

  • Topics: Pharmacology/Toxicology, Pharmacy

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