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Interferons and Their Applications

  • Book
  • © 1984

Overview

Editors:
  1. Paul E. Came

    1. HEM Research Inc., Rockville, USA

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  2. William A. Carter

    1. Clinical Research, Department of Oncology, Orlowitz Cancer Institute, Philadelphia, USA
      Department of Hematology and Oncology, Hahnemann University of Health Sciences, Philadelphia, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 71)

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Table of contents (27 chapters)

  1. Front Matter

    Pages I-XXIV
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  2. Interferons and Their Applications: Past, Present, and Future

    • M. Krim
    Pages 1-22

  3. Assay of Interferons

    • S. E. Grossberg, P. M. Jameson, J. J. Sedmak
    Pages 23-43

  4. Evolution of Interferon Genes

    • D. Gillespie, E. Pequignot, W. A. Carter
    Pages 45-63

  5. Comparative Analysis of Interferon Structural Genes

    • P. B. Sehgal, A. D. Sagar
    Pages 65-77

  6. Comparative Structures of Mammalian Interferons

    • K. C. Zoon, R. Wetzel
    Pages 79-100

  7. Regulatory Control of Interferon Synthesis and Action

    • H. Smith-Johannsen, Y-T. Hou, X-Y. Liu, Y-H. Tan
    Pages 101-135

  8. Application of Recombinant DNA Technology to Expression of Human Interferon Genes

    • S. Panem
    Pages 137-151

  9. The Molecular Mediators of Interferon Action

    • C. Baglioni
    Pages 153-168

  10. The Cellular Effects of Interferon

    • J. L. Taylor, J. L. Sabran, S. E. Grossberg
    Pages 169-204

  11. Interferon Induction by Viruses

    • P. I. Marcus
    Pages 205-232

  12. Interferon Induction by Nucleic Acids: Structure-Activity Relationships

    • P. F. Torrence, E. De Clercq
    Pages 233-258

  13. Production and Characterization of Human Leukocyte Interferon

    • N. O. Hill
    Pages 259-269

  14. Lymphoblastoid Interferon: Production and Characterization

    • N. B. Finter, K. H. Fantes
    Pages 271-286

  15. Fibroblast Interferons: Production and Characterization

    • V. G. Edy
    Pages 287-304

  16. Immune Interferon

    • J. A. Georgiades, S. Baron, W. R. Fleischmann Jr., M. Langford, D. A. Weigent, G. J. Stanton
    Pages 305-337

  17. Comparative Biologic Activities of Human Interferons

    • P. K. Weck, P. E. Came
    Pages 339-355

  18. Manufacture and Safety of Interferons in Clinical Research

    • J. C. Petricciani, E. C. Esber, H. E. Hopps, A. Attallah
    Pages 357-370

  19. Nonpolynucleotide Inducers of Interferon

    • D. A. Stringfellow
    Pages 371-383

  20. Agents Which Modulate the Activity of Interferon

    • D. R. Strayer, W. A. Carter
    Pages 385-402
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Keywords

About this book

Today, the basic mood of researchers and clinical investigators, both at the center and on the periphery of interferon studies, is optimistic regarding the future of interferons as therapeutic substances. Many also feel these polypeptides will prove invaluable probes in unraveling certain fundamental biochemical processes which control the life cycle and developmental pattern of many human cells. In contrast, only a year or two ago, this optimism had given way to an attitude almost of disenchantment as public and scientific expectations were raised steeply, then rapidly waned, as it turns out, prematurely. Both the mUltiple actions of interferons (a virtual cascade of biochemical reactions may be induced, as documented herein) and the high visibility of interferon research provided by the millions of dollars invested both by national health agencies and by multinational pharmaceutical companies, contributed to an upsweep in public attention to drug development probably unprecedented in this century. Virtually every oncologist, it would seem, was plagued by requests for the experimental agent, although they already had therapies of more proven value. As recently as 1980, even though interferon had achieved success against certain cancers and certain viral diseases, the variability in clinical results was seemingly ever present and little evidence emerged to suggest interferons could cure advanced diseases. Why then the resurgence of an optimistic mood? There are almost always many elements which contribute to happiness, and this is certainly true of the broad frontier of interferon and its place in biochemical research and treatment.

Editors and Affiliations

  • HEM Research Inc., Rockville, USA

    Paul E. Came

  • Clinical Research, Department of Oncology, Orlowitz Cancer Institute, Philadelphia, USA

    William A. Carter

  • Department of Hematology and Oncology, Hahnemann University of Health Sciences, Philadelphia, USA

    William A. Carter

Bibliographic Information

  • Book Title: Interferons and Their Applications

  • Editors: Paul E. Came, William A. Carter

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-69178-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1984

  • Softcover ISBN: 978-3-642-69180-5Published: 29 December 2011

  • eBook ISBN: 978-3-642-69178-2Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXIV, 578

  • Topics: Pharmacology/Toxicology, Pharmacy

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