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Drug Toxicity in Embryonic Development II

Advances in Understanding Mechanisms of Birth Defects: Mechanistics Understanding of Human Development Toxicants

  • Book
  • © 1997

Overview

Editors:
  1. Robert J. Kavlock

    1. Reproductive Toxicology Division (MD-71) National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. George P. Daston

    1. Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 124 / 2)

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Table of contents (11 chapters)

  1. Front Matter

    Pages I-XXV
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  2. Pathogenesis and Mechanisms of Drug Toxicity in Development

    1. Front Matter

      Pages 1-1
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    2. Retinoids

      • D. M. Kochhar
      Pages 3-39

    3. Peculiarities and Possible Mode of Actions of Thalidomide

      • R. Neubert, D. Neubert
      Pages 41-119

    4. Anticonvulsant Drugs: Mechanisms and Pathogenesis of Teratogenicity

      • R. H. Finnell, B. Bielec, H. Nau
      Pages 121-159

    5. Cardiovascular Active Drugs

      • B. R. Danielsson, W. S. Webster
      Pages 161-190

    6. Anticoagulants

      • R. M. Pauli
      Pages 191-229

    7. Antiviral Agents

      • R. Stahlmann, S. Klug
      Pages 231-264

    8. Angiotensin-Converting Enzyme Inhibitor Fetopathy

      • M. Barr
      Pages 265-294

    9. Anesthetics

      • M. Fujinaga
      Pages 295-331

    10. Alcohols: Ethanol and Methanol

      • J. M. Rogers, G. P. Daston
      Pages 333-405

    11. Developmental Toxicity of Dioxin: Searching for the Cellular and Molecular Basis of Morphological Responses

      • B. D. Abbott
      Pages 407-433

    12. Endocrine Disruptors: Effects on Sex Steroid Hormone Receptors and Sex Development

      • W. R. Kelce, L. Earl Gray Jr.
      Pages 435-474

  3. Back Matter

    Pages 475-485
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Keywords

About this book

Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.

Editors and Affiliations

  • Reproductive Toxicology Division (MD-71) National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, USA

    Robert J. Kavlock

  • Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, USA

    George P. Daston

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