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The Pharmacology of Sleep

  • Book
  • © 1995

Overview

Editors:
  1. Anthony Kales

    1. Sleep Research and Treatment Center, Pennsylvania State University College of Medicine M.S. Hershey Medical Center, Hershey, USA

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 116)

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Table of contents (20 chapters)

  1. Front Matter

    Pages I-XXVIII
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  2. Evolution of Concepts of Mechanisms of Sleep

    • R. Drucker-Colín, H. Merchant-Nancy
    Pages 1-28

  3. Principles of Sleep Regulation: Implications for the Effect of Hypnotics on Sleep

    • A. A. Borbély
    Pages 29-45

  4. Principles of Chronopharmacology and the Sleep-Wake Rhythm

    • A. E. Reinberg
    Pages 47-63

  5. Pharmacology of the Catecholaminergic System

    • A. Wauquier
    Pages 65-90

  6. The Serotoninergic System and Sleep-Wakefulness Regulation

    • J. Adrien
    Pages 91-116

  7. Pharmacology of the Histaminergic System

    • J. M. Monti
    Pages 117-142

  8. Pharmacology of the Cholinergic System

    • G. Tononi, O. Pompeiano
    Pages 143-210

  9. Pharmacology of the GABAergic/Benzodiazepine System

    • W. E. Müller
    Pages 211-242

  10. Pharmacology of the CNS Peptides

    • S. Inoué
    Pages 243-277

  11. Hormones and Sleep

    • E. Van Cauter
    Pages 279-306

  12. Pharmacology of the Adenosine System

    • M. Radulovacki
    Pages 307-322

  13. Methodological Issues in Pharmacological Studies of Sleep

    • E. O. Bixler, A. N. Vgontzas, A. Kales
    Pages 323-343

  14. Hypnotic Drugs

    • A. Kales, A. N. Vgontzas, E. O. Bixler
    Pages 345-385

  15. Anxiolytic Drugs

    • A. Vela-Bueno
    Pages 387-419

  16. Stimulant Drugs

    • Y. Hishikawa
    Pages 421-442

  17. Neuroleptics, Antihistamines and Antiparkinsonian Drugs: Effects on Sleep

    • C. R. Soldatos, D. G. Dikeos
    Pages 443-464

  18. Antidepressant and Antimanic Drugs

    • R. Fritsch Montero, D. Riemann, M. Berger
    Pages 465-490

  19. Anticonvulsant Drugs

    • A. Baruzzi, F. Albani, R. Riva, E. Sforza, E. Lugaresi
    Pages 491-502

  20. Mechanisms of Benzodiazepine Drug Dependence

    • A. N. Vgontzas, A. Kales
    Pages 503-536
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Keywords

About this book

The last four decades have witnessed considerable advances in our knowledge of the pharmacology of sleep. Both basic and clinical pharmacology have made major contributions toward our current understanding of the complex mechanisms of sleep and wakefulness. In addition, these advances in our understanding of the pharmacology of sleep have benefited the treatment of sleep disorders and various neurologic and psychiatric conditions. This volume is organized into three different parts. The first is a review of the basic mechanisms of sleep and wakefulness and the chronobiology of sleep. The second part reviews the basic pharmacology of the various neuro­ transmitter systems involved in sleep and wakefulness, while the third is clinically oriented and focuses on the effects of a variety of drugs on sleep and wakefulness. The initial part begins with a historical review of the hypotheses of the mechanisms of sleep, evolving from passive to active regulation, and concepts involving sleep-related neurotransmitters and other sleep factors. Then regulation of sleep and wakefulness is discussed in terms of homeostatic, circadian, and ultradian processes. Also discussed is the fact that sleep homeostasis is not disrupted by the administration of hypnotic drugs. This part also reviews time-dependent properties of pharmacologic agents in relation to endogenous biologic rhythms and more specifically to chrono­ pharmacologic changes.

Editors and Affiliations

  • Sleep Research and Treatment Center, Pennsylvania State University College of Medicine M.S. Hershey Medical Center, Hershey, USA

    Anthony Kales

Bibliographic Information

  • Book Title: The Pharmacology of Sleep

  • Editors: Anthony Kales

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-57836-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1995

  • Hardcover ISBN: 978-3-540-58961-7Published: 11 December 1995

  • Softcover ISBN: 978-3-642-63372-0Published: 08 October 2012

  • eBook ISBN: 978-3-642-57836-6Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXVIII, 583

  • Topics: Pharmacology/Toxicology, Cell Biology, Human Physiology, Neurosciences

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