Overview
- Editors:
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Roland Seifert
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Medical School of Hannover Insitute of Pharmakology, Hannover, Germany
- This book gives insight into latest findings in this emerging field of research
- First book to be published on non-canonical cyclic nucleotides
- Provides comprehensive coverage of topic and will present important methodological aspects
- Includes supplementary material: sn.pub/extras
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Table of contents (18 chapters)
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Front Matter
Pages i-viii
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- Sabine Wolter, Fanni Dittmar, Roland Seifert
Pages 25-47
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- K. Adam Morrow, Dara W. Frank, Ron Balczon, Troy Stevens
Pages 67-85
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- Claudius Marondedze, Aloysius Wong, Ludivine Thomas, Helen Irving, Chris Gehring
Pages 87-103
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- Robin Lorenz, Daniela Bertinetti, Friedrich W. Herberg
Pages 105-122
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- Bryan VanSchouwen, Giuseppe Melacini
Pages 123-133
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- Jens Schlossmann, Stefanie Wolfertstetter
Pages 149-167
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- Erich H. Schneider, Roland Seifert
Pages 169-205
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- Susan W. S. Leung, Yuansheng Gao, Paul M. Vanhoutte
Pages 209-228
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- Hirokazu Arimoto, Daiki Takahashi
Pages 253-268
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- Arun K. Mankan, Martina Müller, Gregor Witte, Veit Hornung
Pages 269-289
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- Heike Bähre, Volkhard Kaever
Pages 293-306
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- Frank Schwede, Andreas Rentsch, Hans-Gottfried Genieser
Pages 307-337
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- Manuel Grundmann, Evi Kostenis
Pages 339-357
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- Frank Schwede, Hans-Gottfried Genieser, Andreas Rentsch
Pages 359-384
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Back Matter
Pages 385-387
About this book
The cyclic purine nucleotides 3’,5’-cAMP and 3’,5’-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3’,5’-cAMP and 3’,5’-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3’,5’-cCMP and 3’,5’-cUMP, the purine nucleotide 3’,5’-cIMP, the 2’,3’-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3’,5’-cCMP and 3’,5’-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3’,5’-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.
Editors and Affiliations
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Medical School of Hannover Insitute of Pharmakology, Hannover, Germany
Roland Seifert