Overview
- Editors:
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Vincenzo Zappia
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Institute of Biochemistry of Macromolecules, University of Naples, Naples, Italy
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Anthony E. Pegg
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The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, USA
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Table of contents (67 chapters)
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Ornithine Decarboxylase: Molecular Genetics, Post-Synthetic Modifications and Antizyme
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- Olli A. Jänne, Anne Crozat, Mervi Julkunen, Noreen J. Hickok, Leonard Eisenberg, Evie Melanitou
Pages 1-11
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- C. A. Panagiotidis, S. C. Huang, S. A. Tsirka, D. A. Kyriakidis, E. S. Canellakis
Pages 13-24
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- S. Hayashi, Y. Murakami, S. Matsufuji, M. Nishiyama, R. Kanamoto, T. Kameji
Pages 25-35
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- Margaret E. Brosnan, Yu-Wan Hu
Pages 37-43
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- Flavio Flamigni, Flavio Meggio, Sandra Marmiroli, Carlo Guarnieri, Lorenzo A. Pinna, Claudio M. Caldarera
Pages 45-53
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- J. L. A. Mitchell, M. F. Hicks, H. J. Chen, J. A. Hoff
Pages 55-70
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Enzymes of Polyamine Metabolism and Recycling
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- K. Kashiwagi, S. K. Taneja, Q.-W. Xie, C. W. Tabor, H. Tabor
Pages 73-79
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- David L. Anton, Rusty Kutny
Pages 81-89
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- Giovanna Cacciapuoti, Marina Porcelli, Agata Gambacorta, Teresa Romano, Mario De Rosa
Pages 91-100
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- Anthony E. Pegg, Bruce Stanley, Antti Pajunen, Anne Crozat, Olli A. Jänne
Pages 101-109
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- Terho Eloranta, Olavi Kajander, Leila Kauppinen, Tapani Hyvönen, Annikka Linnala-Kankkunen, Nisse Kalkkinen et al.
Pages 117-126
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- B. Mondovì, P. Riccio, E. Agostinelli
Pages 147-161
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Metabolism of 5′ -Methylthioadenosine in Normal and Transformed Cells
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Front Matter
Pages 163-163
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- Vincenzo Zappia, Fulvio Della Ragione, Gabriele Pontoni, Vincenzo Gragnaniello, Maria Cartenì-Farina
Pages 165-177
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- Dennis A. Carson, Tsutomu Nobori, E. Olavi Kajander, Carlos J. Carrera, Masaru Kubota, Hisashi Yamanaka
Pages 179-185
About this book
This book contains the scientific contributions presented at an International Symposium held in Sorrento, Italy, in June 1988 under the auspices of the University of Naples, the Italian Society of Biochemistry, and the National Research Council. The modern history of polyamines dates back to 1958 when the Tabors and Rosenthal first described the outlines of their biological synthesis. From then on, and particularly in the last ten years, a veri table explosion of Literature, characterized by thousands of papers, has witnessed the interest of the scientific community toward these molecules. Perhaps the old statement that "polyamines are molecules in search of a function" is no longer true today. A large number of effects exerted by these simple molecules are well known, and in many cases the mechanisms underlying these effects have been elucidated. The first section of the volume is entirely devoted to the enzymology and molecular biology of ornithine decarboxylase. Since its discovery by Gale more than forty years ago, this can be considered among the most widely studied enzymes in biology, and one of the most complex models in enzyme regulation. The mechanism of control of the enzyme activity at the transcriptional, post-transcriptional and post-translational levels, as well as the fine regulation by antizyme, are discussed in detail. The second group of contributions deals wi th AdoMet decarboxylase, propylamine transferase, polyamine oxidase and the other enzymes related to polyamine interconversion and regeneration.
Editors and Affiliations
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Institute of Biochemistry of Macromolecules, University of Naples, Naples, Italy
Vincenzo Zappia
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The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, USA
Anthony E. Pegg