Overview
- Editors:
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Ira B. Black
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Cornell University Medical College, New York, USA
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Table of contents (22 chapters)
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Embryogenesis and Morphogenesis of the Nervous System: Session Chairman: James A. Weston
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- James A. Weston, John Girdlestone, Gary Ciment
Pages 51-62
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- Michael J. Bastiani, Corey S. Goodman
Pages 63-84
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Developmental Expression of Neuronal Phenotypic Characters: Session Chairman: Ira B. Black
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- Gerald D. Fischbach, Lorna W. Role, Richard I. Hume
Pages 107-115
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- Ira B. Black, Joshua E. Adler, Martha C. Bohn, G. Miller Jonakait, John A. Kessler, Keith A. Markey
Pages 117-130
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Nerve Growth Factor as a Model Growth Factor: Session Chairman: Eric M. Shooter
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Front Matter
Pages 131-131
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- Lloyd A. Greene, David E. Burstein, James L. Connolly, Steven H. Green, P. John Seeley, Michael L. Shelanski
Pages 133-141
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- Eugene M. Johnson Jr., Pamela Toy Manning
Pages 165-176
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- Stanley M. Crain, Edith R. Peterson
Pages 177-200
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- Arne Sutter, Markus Hosang, Ronald D. Vale, Eric M. Shooter
Pages 201-214
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New Neuronal Growth Factors: Session Chairman: Hans Thoenen
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Front Matter
Pages 215-215
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- Ted Ebendal, Lars Olson, Åke Seiger, Makonnen Belew
Pages 231-242
About this book
A central problem in neurobiology concerns mechanisms that generate the pro found diversity and specificity of the nervous system. What is the substance of diversification and specificity at the molecular, cellular, and systems levels? 4 How, for example, do 1011 neurons each form approximately 10 interconnec tions, allowing normal physiological function? How does disruption of these processes result in human disease? These proceedings represent the efforts of molecular biologists, embryologists, neurobiologists, and clinicians to approach these issues. in this volume are grouped by subject to present the varieties The chapters of methods used to approach each individual area. Section I deals with embry ogenesis and morphogenesis of the nervous system. In Chapter 3, Weston and co-workers describe the use of monoclonal antibodies that recognize specific neuronal epitopes (including specific gangliosides) for the purpose of defining heterogeneity in the neural crest, an important model system. Immunocyto chemical analysis reveals the existence of distinct sUbpopulations within the crest at extremely early stages; cells express neuronal or glial binding patterns at the time of migration. Consequently, interactions with the environment may select for predetermined populations. Le Douarin reaches similar conclusions in Chapter 1 by analyzing migratory pathways and developmental potentials in crest of quail-
Editors and Affiliations
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Cornell University Medical College, New York, USA
Ira B. Black