Overview
- Editors:
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Dolph L. Hatfield
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National Cancer Institute, USA
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Marla J. Berry
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University of Hawaii, USA
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Vadim N. Gladyshev
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Univeristy of Nebraska, USA
Features the many new discoveries have occurred since the 1st edition on Selenium was published in 2001
New investigators who have made important contributions to the field have been added as chapter authors
Includes supplementary material: sn.pub/extras
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Table of contents (35 chapters)
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Front Matter
Pages i-xxiii
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Selenium: A historical perspective
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Biosynthesis of selenocysteine and its incorporation into protein
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- August Böck, Michael Rother, Marc Leibundgut, Nenad Ban
Pages 9-28
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- Bradley A. Carlson, Xue-Ming Xu, Rajeev Shrimali, Aniruddha Sengupta, Min-Hyuk Yoo, Robert Irons et al.
Pages 29-37
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- Gustavo Salinas, Hétor Romero, Xue-Ming Xu, Bradley A. Carlson, Dolph L. Hatfield, Vadim N. Gladyshev
Pages 39-50
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- Christine Allmang, Alain Krol
Pages 51-61
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- Donna M. Driscoll, Paul R. Copeland
Pages 63-72
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- Peter R. Hoffmann, Marla J. Berry
Pages 73-82
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- Andrea L Small-Howard, Maria J Berry
Pages 83-95
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Selenium-containing proteins
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- Raymond F. Burk, Gary E. Olson, Kristina E. Hill
Pages 111-122
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- Hwa-Young Kim, Vadim N. Gladyshev
Pages 123-133
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- Chrissa Kioussi, Philip D. Whanger
Pages 135-140
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- Vyacheslav M. Labunskyy, Vadim N. Gladyshev, Dolph L. Hatfield
Pages 141-148
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- Leopold Flohé, Regina Brigelius-Flohé
Pages 161-172
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- Xin Gen Lei, Wen-Hsing Cheng
Pages 173-182
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About this book
The discovery of selenoproteins in 1973 was the starting point for today's flourishing selenium field [1,2]. It provided evidence that selenium had biochemical functions that could account for its nutritional effects [3,4]. Further, it opened the selenium field to investigation by the methods of biochemistry, which led to the identification of several more selenoproteins and showed that selenocysteine was the form of the element in animal selenoproteins and in most bacterial ones. Although noteworthy efforts were made to uncover the mechanism of selenocysteine and selenoprotein synthesis using biochemical methods, the problem yielded only when attacked with the methods of molecular biology [5,6]. The bacterial mechanism was characterized first; characterization of the animal mechanism is a work in progress. It is interesting to note that the only genes that are devoted to selenium metabolism are those that support selenoprotein synthesis and selenocysteine catabolism. Consequently, it seems likely that competition for selenium between selenoprotein synthesis and the production of selenium excretory metabolites [7] controls who- body selenium homeostasis. The physiological functions of selenium derive fi-om the catalytic and physical properties of selenoproteins. Selenoproteins such as the glutathione peroxidases and the thioredoxin reductases have redox activities that allow them to serve in oxidant defense. The deiodinases use their redox activities to activate and inactivate thyroid hormones. From these two examples, it can be seen that selenoprotein functions are diverse while having in common a redox mechanism.
Editors and Affiliations
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National Cancer Institute, USA
Dolph L. Hatfield
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University of Hawaii, USA
Marla J. Berry
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Univeristy of Nebraska, USA
Vadim N. Gladyshev