Handbook of Experimental Pharmacology

Platelets and Their Factors

Editors: Bruchhausen, Franz von, Walter, Ulrich (Eds.)

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About this book

Platelets playa fundamental, life-saving role in hemostasis and blood clotting at sites of vascular injury. Unwanted platelet activation and arterial thombus formation are, however, implicated in the onset of myocardial infarction, stroke, and other cardiovascular diseases. Acceptance that platelets play a major role in the pathogenesis of atherosclerosis including coronary heart disease has revolutionized the pharmacological treatment of cardiovascular diseases, and aspirin is now an essential antiplatelet drug and the golden standard for future developments. Yet the search for better and perhaps safer antiplatelet drugs is one of the most active areas of investigation in both basic and clinical research. Platelets, especially human platelets, have also emerged as one of the major models for the study of inter- and intracellular signal transduction pathways. Many biochemists, cell biologists, pharmacologists, pathologists, hematologists, and cardiologists find platelets useful for studying processes such as adhesion, inside-out and outside-in signalling through the plasma membrane, channels, calcium homeostasis, protein kinases, the network of intracellular signal transduction cascades, and the release of vasoactive substances. The aim of the editors has been to compile chapters summarizing the current state-of-the-art information on the biochemistry, cell biology, pharmacology, and physiologic and pathophysiologic roles of human platelets. We hope that this volume represents the major aspects of current platelet research although it is perhaps inevitable that certain areas are covered less thoroughly than others. We would like to acknowledge the excellent help and support of the Springer-Verlag staff, in particular that of Ms. Doris Walker.

Table of contents (29 chapters)

  • Megakaryocytopoiesis: The Megakaryocyte/Platelet Haemostatic Axis

    Brown, A. S. (et al.)

    Pages 3-26

  • Human Platelet Morphology/Ultrastructure

    Morgenstern, E.

    Pages 27-60

  • Platelet Adhesion

    Zanten, G. H. (et al.)

    Pages 61-81

  • Platelet Aggregation

    Ruf, A. (et al.)

    Pages 83-98

  • Platelet Receptors: The Thrombin Receptor

    Siess, W.

    Pages 101-116

Buy this book

eBook $74.99
price for USA (gross)
  • ISBN 978-3-642-60639-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $99.00
price for USA
  • ISBN 978-3-642-64488-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Platelets and Their Factors
Editors
  • Franz von Bruchhausen
  • Ulrich Walter
Series Title
Handbook of Experimental Pharmacology
Series Volume
126
Copyright
1997
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-60639-7
DOI
10.1007/978-3-642-60639-7
Softcover ISBN
978-3-642-64488-7
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XXVIII, 753
Number of Illustrations and Tables
2 illustrations in colour
Topics