Handbook of Experimental Pharmacology

Neuronal Nicotinic Receptors

Editors: Clementi, F., Fornasari, D., Gotti, C. (Eds.)

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About this book

Neuronal nicotinic receptors are key molecules for signal transduction in a number of neuronal pathways. They are widely distributed in the brain and are known to be involved in cognitive tasks, including learning and memory, in smoking addiction and in several brain diseases, such as Alzheimer's and Parkinson's dementias, schizophrenia, and epilepsy. This book provides a comprehensive review of the field, starting with a historical perspective and dealing with the molecular structure of these receptors, their biophysical and pharmacological properties, their distribution in central and peripheral nervous systems, and their major involvement in brain functions. Particular emphasis is paid to drugs (both new and old) that are useful in the diagnosis and treatment of diseases involving neuronal nicotinic receptors. Finally, the relevance of these receptors in smoking addiction is carefully evaluated, together with future trends and the latest results.

Table of contents (26 chapters)

  • The History of the Neuronal Nicotinic Receptors

    Brown, D. A.

    Pages 3-11

  • Distribution of Cholinergic Neurons in the Mammalian Brain with Special Reference to their Relationship with Neuronal Nicotinic Acetylcholine Receptors

    Zoli, M.

    Pages 13-30

  • Gene Structure and Transcriptional Regulation of the Neuronal Nicotinic Acetylcholine Receptors

    Matter, J.-M. (et al.)

    Pages 33-55

  • Transcriptional Regulation of Neuronal nAChR Subunit Genes

    Deneris, E. S.

    Pages 57-77

  • Contributions of Studies of the Nicotinic Receptor from Muscle to Defining Structural and Functional Properties of Ligand-Gated Ion Channels

    Taylor, P. (et al.)

    Pages 79-100

Buy this book

eBook $74.99
price for USA (gross)
  • ISBN 978-3-642-57079-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $99.00
price for USA
  • ISBN 978-3-642-63027-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Neuronal Nicotinic Receptors
Editors
  • F. Clementi
  • D. Fornasari
  • C. Gotti
Series Title
Handbook of Experimental Pharmacology
Series Volume
144
Copyright
2000
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heildelberg
eBook ISBN
978-3-642-57079-7
DOI
10.1007/978-3-642-57079-7
Softcover ISBN
978-3-642-63027-9
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XXXI, 821
Number of Illustrations and Tables
83 b/w illustrations, 4 illustrations in colour
Topics