Handbook of Experimental Pharmacology

Modern Anesthetics

Editors: Schüttler, Jürgen, Schwilden, Helmut (Eds.)

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About this book

Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. “The very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.

Table of contents (22 chapters)

  • The Site of Anesthetic Action

    Urban, B. W.

    Pages 3-29

  • Inhibitory Ligand-Gated Ion Channels as Substrates for General Anesthetic Actions

    Zeller, A. (et al.)

    Pages 31-51

  • Actions of Anesthetics on Excitatory Transmitter-Gated Channels

    Akk, G. (et al.)

    Pages 53-84

  • Voltage-Gated Ion Channels

    Nau, C.

    Pages 85-92

  • G-Protein-Coupled Receptors

    Sanders, R. D. (et al.)

    Pages 93-117

Buy this book

eBook $479.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-3-540-74806-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $609.00
price for USA
valid through November 5, 2017
  • ISBN 978-3-540-72813-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $609.00
price for USA
valid through November 5, 2017
  • ISBN 978-3-642-09192-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Modern Anesthetics
Editors
  • Jürgen Schüttler
  • Helmut Schwilden
Series Title
Handbook of Experimental Pharmacology
Series Volume
182
Copyright
2008
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-74806-9
DOI
10.1007/978-3-540-74806-9
Hardcover ISBN
978-3-540-72813-9
Softcover ISBN
978-3-642-09192-6
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XVI, 498
Number of Illustrations and Tables
107 b/w illustrations, 5 illustrations in colour
Topics